A #monoclonal anti-hemagglutinin stem #antibody modified with #zanamivir protects against both #influenza A and B viruses, https://etidiohnew.blogspot.com/2025/04/a-monoclonal-anti-hemagglutinin-stem.html
Dairy #cattle #herds mount a characteristic #antibody response to highly pathogenic #H5N1 avian #influenza viruses, https://etidiohnew.blogspot.com/2025/04/dairy-cattle-herds-mount-characteristic.html
#Scientists Uncover Potent #Antibody That Neutralizes 75% of #Norovirus Strains
Neutralizing #Antibody #Response to #Influenza A(#H5N1) Virus in Dairy #Farm #Workers, #Michigan, #USA, https://etidiohnew.blogspot.com/2025/03/neutralizing-antibody-response-to.html
Inactivated Zoonotic #Influenza A(#H5N8) #Vaccine Induces Robust #Antibody Responses Against Recent HPAI Clade 2.3.4.4b A(#H5N1) Viruses, https://etidiohnew.blogspot.com/2025/02/inactivated-zoonotic-influenza-ah5n8.html
Small antibody offers broad protection against influenza
https://medicalxpress.com/news/2025-01-small-antibody-broad-influenza.html
A locally administered single-cycle #influenza #vaccine expressing a non-fusogenic stabilized #hemagglutinin stimulates strong T-cell and neutralizing #antibody #immunity, https://etidiohnew.blogspot.com/2025/01/a-locally-administered-single-cycle.html
#Epitope analysis methods can elucidate the basis of #antibody target specificity, but are often limited in resolution. This study presents DECODE, a high-throughput approach that provides single amino acid resolution for antibodies that recognize linear epitopes #PLOSBiology https://plos.io/40LPxxQ
#Antibody responses against #influenza A decline with successive years of annual influenza #vaccination, https://etidiohnew.blogspot.com/2025/01/antibody-responses-against-influenza.html
Asymptomatic #infection and #antibody #prevalence to co-occurring avian #influenza viruses vary substantially between sympatric #seabird species following #H5N1 #outbreaks, https://etidiohnew.blogspot.com/2025/01/asymptomatic-infection-and-antibody.html
Identification of a broad-inhibition #influenza #neuraminidase #antibody from pre-existing memory B cells, https://etidiohnew.blogspot.com/2025/01/identification-of-broad-inhibition.html
Structural basis of broad #protection against #influenza virus by a #human #antibody targeting the #neuraminidase active site via a recurring motif in CDR H3
Source: BioRxIV, AbstractInfluenza viruses evolve rapidly, driving seasonal epidemics and posing global pandemic threats. While neuraminidase (NA) has emerged as a vaccine target, shared molecular features of NA antibody responses are still not well understood. Here, we describe cryo-electron microscopy structures…
Protective threshold of a potent neutralizing #Zika virus monoclonal #antibody in rhesus #macaques
Source: Journal of Virology, ABSTRACTZika virus (ZIKV) is a mosquito-borne flavivirus that caused a global pandemic in 2016–2017 with continued ongoing transmission at low levels in several countries. In the absence of an approved ZIKV vaccine, neutralizing monoclonal antibodies (mAbs) provide an option for the prevention and treatment of ZIKV infection. Previous studies…
Evolving #antibody #response to #SARS-CoV-2 #antigenic #shift from #XBB to #JN1
Source: Nature, AbstractThe continuous evolution of SARS-CoV-2, particularly the emergence of BA.2.86/JN.1 lineage replacing XBB, necessitates re-evaluation of vaccine compositions 1–3. Here, we provide a comprehensive analysis of the humoral immune response to XBB and JN.1 human exposure. We demonstrate the antigenic distinctiveness of XBB and JN.1 lineages in SARS-CoV-2-naive individuals,…
Neutralizing #antibody #evasion of #SARS-CoV-2 #JN1 derivatives #KP3, #KP311, #LB1, and #XEC
Source: BioRxIV, AbstractThe emergence of SARS-CoV-2 variants poses ongoing challenges to vaccine efficacy. We evaluated neutralizing antibody responses against JN.1 and its derivatives (KP.3, KP.3.1.1, LB.1, and XEC) in healthcare workers who received seven doses of BNT162b2, including XBB.1.5 monovalent vaccine. In COVID-19-naive individuals, KP.3.1.1 and LB.1 showed…
Immune history shapes #human #antibody #responses to #H5N1 #influenza viruses {Repost}
Source: MedRxIV, AbstractAvian H5N1 influenza viruses are circulating widely in cattle and other mammals and pose a risk for a human pandemic. Previous studies suggest that older humans are more resistant to H5N1 infections due to childhood imprinting with other group 1 viruses (H1N1 and H2N2); however, the immunological basis for this is incompletely understood. Here we show that…
Life Science Washington Institute Honors ProfoundBio | News https://www.byteseu.com/508121/ #2024EntrepreneurialAchievementAward #adcs #AntibodyDrugConjugates #Antibody–drugConjugate #BaitengZhao #bellevue #business #Cancer #China #Denmark #entrepreneurship #genmab #Health #HealthCare #HealthSciences #Innovation #LifeScienceWashington #LifeScienceWashingtonInstitute #profoundbio #RichardGiersch #Science #seattle #shanghai #suzhou #TaeH.Han #WashingtonInnovationNetwork #win #woodinville
A #human #monoclonal #antibody targeting the monomeric #N6 #neuraminidase confers protection against avian #H5N6 #influenza virus infection
Source: Nature Communications, AbstractThe influenza neuraminidase (NA) is a potential target for the development of a next-generation influenza vaccine, but its antigenicity is not well understood. Here, we isolate an anti-N6 human monoclonal antibody, named 18_14D, from an H5N6 avian influenza virus (AIV) infected patient. The…
