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#CellBiology

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Victoria Stuart 🇨🇦 🏳️‍⚧️

Cells are swapping their mitochondria: Health implications?
nature.com/articles/d41586-025
news.ycombinator.com/item?id=4

Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.

Power/potential of mitochondria transfer
nature.com/articles/s41586-023

Tunneling nanotube
en.wikipedia.org/wiki/Tunnelin
Role: intercellular transfer
en.wikipedia.org/wiki/Tunnelin

www.nature.comCells are swapping their mitochondria. What does this mean for our health?Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.
#mitochondria#MolecularBiology#CellBiology
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ma𝕏pool

3rd method if inheritance besides DNA and RNA: Amyloid-like protein structures that have the ability to replicate making them possible inheritance vectors.

Noncanonical inheritance of phenotypic information by protein amyloids nature.com/articles/s41556-024

>we identify amyloid-like protein structures that are stably inherited in wild-type animals and influence traits. Their perturbation by genetic, environmental or pharmacological treatments leads to developmental phenotypes that can be epigenetically passed onto progeny.

NatureNoncanonical inheritance of phenotypic information by protein amyloids - Nature Cell BiologyEroglu et al. describe protein amyloid structures that are stably inherited across generations and transmit epigenetic memory in Caenorhabditis elegans. MSTR protein loss results in a transgenerational feminization phenotype through ectopic GLD-1 expression.
#biology#cellbiology#epigenetics
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Stephen Royle

Very interesting preprint from Jurgen Klingauf and colleagues demonstrating that synaptic vesicle retrieval is clathrin-mediated.

The debate over the mechanism has been going since the 1970s. In recent years, ultra-fast endocytosis has become accepted. In this paper it's argued that if you look at retrieval of cargo, rather than membrane, then it is mainly driven by clathrin.

biorxiv.org/content/10.1101/20

bioRxiv · A slow and clathrin-dependent mode of compensatory endocytosis in hippocampal boutons at near-physiological temperatureThe mode of presynaptic compensatory endocytosis has been controversial for decades. Recently, an ultrastructural study on synaptic membrane retrieval following synaptic vesicle fusion revealed an ultrafast mechanism of endocytosis in mouse hippocampal synapses at physiological temperature. Using live cell imaging of single-vesicle exo- and endocytosis in mouse hippocampal synapses, combined with accelerated optogenetic acidification of synaptic vesicles, we found that compensatory endocytosis occurs mostly through a slow clathrin-dependent and actin-independent mode at both room and physiological temperatures. ### Competing Interest Statement The authors have declared no competing interest.
#neuroscience#CellBiology
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MPI for the Science of Light

Neighborhood dispute among cells: Whoever successfully transmits force wins

Cells constantly compete, eliminating weaker ones to maintain tissue health. Researchers from #MPZPM, #InstitutJacquesMonod and #NielsBohrInstitute discovered a new strategy in mechanical cell competition: the ability to transmit force determines the winner. Their findings challenge classical views on #CellCompetition.

Learn more 👉 mpzpm.mpg.de/news/news-details

#science #research #cellbiology

📸 Lucas Anger

Drawing showing how mechanical forces shape cell competition and elimination at tissue boundaries.
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