Dave Troy @davetroy

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**CITO Greenhouse** @cito_greenhouse@mastodon.social · 5d

**katch wreck** @katchwreck@mastodon.social · Mar 11

katch wreck @katchwreck@mastodon.social

`Here we report that high expression of astrocytic cannabinoid receptor 1 (CB1) in the nucleus accumbens (NAc) shell, particularly in the end-feet ensheathing blood vessels, is associated with resilience during chronic social stress in adult male mice. Viral-mediated overexpression of Cnr1 in astrocytes of the NAc shell results in baseline anxiolytic effects and dampens stress-induced anxiety- and depression-like behaviors in male mice.`

https://www.nature.com/articles/s41593-025-01891-9

NatureAstrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced blood–brain barrier alterations - Nature NeuroscienceThe mechanisms of neurovascular adaptations underlying stress resilience remain unclear. Here the authors show that the astrocytic endocannabinoid system modulates the blood–brain barrier changes during stress in adult mice.

#BBB #brain #endocannabinoid

Continued thread

**Xamanismo Coletivo** @eliasulrich@hachyderm.io · Apr 20, 2024

Apr 20, 2024

Xamanismo Coletivo @eliasulrich@hachyderm.io

"#CarlSagan, the astronomer & science communicator, speculated that #cannabis might be the 1st ever domesticated plant, the one that drove the dawn of #agriculture. The #endocannabinoid system, that regulates other systems in the human body, is where #Cannabinoids like #THC fit like a lock & a key. This is how foundational a relationship can get… you have to love that plant a whole lot to create agriculture simply to have a steady supply."
https://pca.st/wjj3qblb?t=20m8s

Pocket CastsA Blunt Conversation about Cannabis w/ David Bienenstock - UpstreamConversations and audio documentaries exploring a wide variety of themes pertaining to economics and politics, hosted by Della Z Duncan and Robert R. Raymond

**DoomsdaysCW** @DoomsdaysCW@kolektiva.social · Feb 8, 2024

Feb 8, 2024

DoomsdaysCW @DoomsdaysCW@kolektiva.social

#Cannabinoids as novel #AntiInflammatory drugs

by Prakash Nagarkatti, et al.
October, 2009

Abstract:

"Cannabinoids are a group of compounds that mediate their effects through cannabinoid receptors. The discovery of Δ9-tetrahydrocannabinol (#THC) as the major psychoactive principle in marijuana, as well as the identification of #cannabinoid receptors and their endogenous ligands, has led to a significant growth in research aimed at understanding the physiological functions of cannabinoids. Cannabinoid receptors include CB1, which is predominantly expressed in the brain, and CB2, which is primarily found on the cells of the immune system. The fact that both CB1 and CB2 receptors have been found on #immune cells suggests that cannabinoids play an important role in the regulation of the immune system. Recent studies demonstrated that administration of THC into mice triggered marked apoptosis in T cells and dendritic cells, resulting in immunosuppression. In addition, several studies showed that cannabinoids downregulate #cytokine and chemokine production and, in some models, upregulate T-regulatory cells (Tregs) as a mechanism to suppress #inflammatory responses. The #endocannabinoid system is also involved in #immunoregulation. For example, administration of endocannabinoids or use of inhibitors of enzymes that break down the endocannabinoids, led to immunosuppression and recovery from immune-mediated injury to organs such as the liver. Manipulation of endocannabinoids and/or use of exogenous cannabinoids in vivo can constitute a potent treatment modality against inflammatory disorders. This review will focus on the potential use of cannabinoids as a new class of anti-inflammatory agents against a number of inflammatory and autoimmune diseases that are primarily triggered by activated T cells or other cellular immune components."

Executive summary

- Cannabinoids, the active components of #CannabisSativa, and endogenous cannabinoids mediate their effects through activation of specific cannabinoid receptors known as cannabinoid receptor 1 and 2 (CB1 and CB2).

- The cannabinoid system has been shown both in vivo and in vitro to be involved in regulating the immune system through its immunomodulatory properties.

- Cannabinoids suppress inflammatory response and subsequently attenuate disease symptoms. This property of cannabinoids is mediated through multiple pathways such as induction of apoptosis in activated immune cells, suppression of cytokines and chemokines at inflammatory sites and upregulation of FoxP3+ regulatory T cells.

- Cannabinoids have been tested in several experimental models of autoimmune disorders such as #MultipleSclerosis, #RheumatoidArthritis, #colitis and #hepatitis and have been shown to protect the host from the pathogenesis through induction of multiple anti-inflammatory pathways.

- Cannabinoids may also be beneficial in certain types of #cancers that are triggered by #ChronicInflammation In such instances, cannabinoids can either directly inhibit tumor growth or suppress inflammation and tumor angiogenesis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828614/

PubMed Central (PMC)Cannabinoids as novel anti-inflammatory drugsCannabinoids are a group of compounds that mediate their effects through cannabinoid receptors. The discovery of Δ[9] -tetrahydrocannabinol (THC) as the major psychoactive principle in marijuana, as well as the identification of cannabinoid receptors ...

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