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Giuseppe MichieliBeyond <a href="https://mstdn.science/tags/MERS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MERS</a>: <a href="https://mstdn.science/tags/Merbecovirus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Merbecovirus</a> <a href="https://mstdn.science/tags/receptor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#receptor</a> plasticity calls for emergence <a href="https://mstdn.science/tags/preparedness" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#preparedness</a>, <a href="https://etidiohnew.blogspot.com/2025/04/beyond-mers-merbecovirus-receptor.html" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://etidiohnew.blogspot.com/2025/04/beyond-mers-merbecovirus-receptor.html</a>

Scienza et MagiaHKU5-CoV il nuovo coronavirus trasmissibile. Un team cinese scopre un nuovo coronavirus trasmissibile all'uomo. Studio condotto sui pipistrelli da una famosa virologa di Wuhan. Un team cinese ha scoperto un nuovo coronavirus dei pipistrelli che comporta il rischio di trasmissione da animale a uomo perché utilizza lo stesso recettore umano del virus che causa il Covid-19. Lo studio, riporta il South China...<a href="https://mastodon.uno/tags/coronavirus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#coronavirus</a> <a href="https://mastodon.uno/tags/Covid19" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Covid19</a> <a href="https://mastodon.uno/tags/HKU5CoV" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#HKU5CoV</a> <a href="https://mastodon.uno/tags/merbecovirus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#merbecovirus</a> <a href="https://mastodon.uno/tags/pipistrelli" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#pipistrelli</a> <a href="https://scienzamagia.eu/sociale-collettivita/hku5-cov-il-nuovo-coronavirus-trasmissibile/" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://scienzamagia.eu/sociale-collettivita/hku5-cov-il-nuovo-coronavirus-trasmissibile/</a>

Giuseppe Michieli<a href="https://mstdn.science/tags/Bat" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Bat</a>-infecting <a href="https://mstdn.science/tags/merbecovirus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#merbecovirus</a> HKU5-CoV <a href="https://mstdn.science/tags/lineage" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#lineage</a> 2 can use <a href="https://mstdn.science/tags/human" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#human</a> <a href="https://mstdn.science/tags/ACE2" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ACE2</a> as a cell entry receptor, <a href="https://etidiohnew.blogspot.com/2025/02/bat-infecting-merbecovirus-hku5-cov.html" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://etidiohnew.blogspot.com/2025/02/bat-infecting-merbecovirus-hku5-cov.html</a>

ETIDIoHOngoing <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/evolution/" target="_blank">#Evolution</a> of #MERS-CoV, #Saudi Arabia, 2023–2024Source: Emerging Infectious Diseases Journal, <a href="https://wwwnc.cdc.gov/eid/article/31/1/24-1030_article" rel="nofollow noopener noreferrer" target="_blank">https://wwwnc.cdc.gov/eid/article/31/1/24-1030_article</a> Abstract Middle East respiratory syndrome coronavirus (MERS-CoV) circulates in dromedary camels in the Arabian Peninsula and occasionally causes spillover infections in humans. MERS-CoV diversity is poorly understood because of the lack of sampling during the COVID-19 pandemic. We collected 558 swab samples from dromedary camels in Saudi Arabia during November 2023–January 2024. We found 39% were positive for MERS-CoV RNA by reverse transcription PCR. We sequenced 42 MERS-CoVs and 7 human 229E-related coronaviruses from camel swab samples by using high-throughput sequencing. Sequences from both viruses formed monophyletic clades apical to recently available genomes. MERS-CoV sequences were most similar to B5 lineage sequences and harbored unique genetic features, including novel amino acid polymorphisms in the spike protein. Further characterization will be required to understand their effects. MERS-CoV spillover into humans poses considerable public health concerns. Our findings indicate surveillance and phenotypic studies are needed to identify and monitor MERS-CoV pandemic potential.____<a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/abstract/" target="_blank">#abstract</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/betacoronavirus/" target="_blank">#betacoronavirus</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/camels-2/" target="_blank">#camels</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/coronavirus-2/" target="_blank">#coronavirus</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/covid/" target="_blank">#covid</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/covid-19/" target="_blank">#COVID19</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/health/" target="_blank">#health</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/merbecovirus/" target="_blank">#merbecovirus</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/mers-cov-2/" target="_blank">#mersCov</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/research-2/" target="_blank">#research</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/sars-cov-2/" target="_blank">#sarsCov2</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/saudi-arabia/" target="_blank">#SAUDIARABIA</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/vaccine/" target="_blank">#vaccine</a>

ETIDIoHThe #time between #symptom onset and various clinical #outcomes: a statistical #analysis of #MERS-CoV #patients in #Saudi ArabiaSource: Royal Society Open Science, <a href="https://royalsocietypublishing.org/doi/10.1098/rsos.240094" rel="nofollow noopener noreferrer" target="_blank">https://royalsocietypublishing.org/doi/10.1098/rsos.240094</a> Abstract In this study, we investigate the impact of demographic characteristics on Middle East respiratory syndrome coronavirus (MERS-CoV) cases in Saudi Arabia, specifically focusing on the time intervals between symptom onset and key events such as hospitalization, case confirmation, reporting and death. We estimate these intervals using data from 2196 cases occurring between June 2012 and January 2020, partitioning the data into four age groups (0–24 years, 25–49 years, 50–74 years and 75–100 years). The duration from symptom onset to hospitalization varies between age cohorts, ranging from 4.03 to 4.75 days, with the 75–100 age group experiencing the longest delay. The interval from symptom onset to case confirmation spans 5.83–8.24 days, and again, the 75–100 age group faces the lengthiest delay. The interval from symptom onset and case reporting ranges from 7.0 to 9.8 days, with the 75–100 age group experiencing the longest delay. The period from symptom onset to death varies across age groups (12.3–16.1 days), with elevated mortality rates during outbreaks. Importantly, we observe age-based differences in the risk of hospitalization and other measures of infection severity, including the probability of death conditional on hospitalization. Careful quantification of epidemiological characteristics, including inference of key epidemiological periods and assessments of differences between cases of different ages, plays a crucial role in understanding the progression of MERS-CoV outbreaks and formulating effective public health strategies to mitigate their impact.____<a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/abstract/" target="_blank">#abstract</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/betacoronavirus/" target="_blank">#betacoronavirus</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/coronavirus-2/" target="_blank">#coronavirus</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/health/" target="_blank">#health</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/human-2/" target="_blank">#human</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/merbecovirus/" target="_blank">#merbecovirus</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/mers-cov-2/" target="_blank">#mersCov</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/news/" target="_blank">#news</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/research-2/" target="_blank">#research</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/saudi-arabia/" target="_blank">#SAUDIARABIA</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/vaccine/" target="_blank">#vaccine</a>

ETIDIoHSource: Journal of Virology, <a href="https://journals.asm.org/doi/10.1128/jvi.01305-24" rel="nofollow noopener noreferrer" target="_blank">https://journals.asm.org/doi/10.1128/jvi.01305-24</a> ABSTRACT Human-to-human transmission of the highly pathogenic Middle East respiratory syndrome coronavirus (MERS-CoV) is currently inefficient. However, there is concern that the virus might mutate and thereby increase its transmissibility and thus pandemic potential. The pandemic SARS-CoV-2 depends on a highly cleavable furin motif at the S1/S2 site of the viral spike (S) protein for efficient lung cell entry, transmission, and pathogenicity. Here, by employing pseudotyped particles, we investigated whether augmented cleavage at the S1/S2 site also increases MERS-CoV entry into Calu-3 human lung cells. We report that polymorphism T746K at the S1/S2 cleavage site or optimization of the furin motif increases S protein cleavage but not lung cell entry. These findings suggest that, unlike what has been reported for SARS-CoV-2, a highly cleavable S1/S2 site might not augment MERS-CoV infectivity for human lung cells.____<a href="https://etidioh.wordpress.com/2024/10/29/acquisition-of-a-multibasic-cleavage-site-does-not-increase-mers-cov-entry-into-calu-3-human-lung-cells/" class="" rel="nofollow noopener noreferrer" target="_blank">https://etidioh.wordpress.com/2024/10/29/acquisition-of-a-multibasic-cleavage-site-does-not-increase-mers-cov-entry-into-calu-3-human-lung-cells/</a><a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/abstract/" target="_blank">#abstract</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/betacoronavirus/" target="_blank">#betacoronavirus</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/covid/" target="_blank">#covid</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/covid-19/" target="_blank">#COVID19</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/health/" target="_blank">#health</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/merbecovirus/" target="_blank">#merbecovirus</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/mers-cov-2/" target="_blank">#mersCov</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/research-2/" target="_blank">#research</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/sarbecovirus/" target="_blank">#sarbecovirus</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/sars-cov-2/" target="_blank">#sarsCov2</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/science/" target="_blank">#science</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/vaccine/" target="_blank">#vaccine</a>

Giuseppe MichieliContrasting roles of <a href="https://mstdn.science/tags/MERS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MERS</a>-CoV and <a href="https://mstdn.science/tags/SARS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#SARS</a>-CoV-2 internal <a href="https://mstdn.science/tags/proteins" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#proteins</a> in <a href="https://mstdn.science/tags/pathogenesis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#pathogenesis</a> in mice, mBio: <a href="https://doi.org/10.1128/mbio.02476-23" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://doi.org/10.1128/mbio.02476-23</a> <a href="https://mstdn.science/tags/research" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#research</a> <a href="https://mstdn.science/tags/betacoronavirus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#betacoronavirus</a> <a href="https://mstdn.science/tags/sarbecovirus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#sarbecovirus</a> <a href="https://mstdn.science/tags/merbecovirus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#merbecovirus</a>

Giuseppe MichieliStructural basis for translation <a href="https://mstdn.science/tags/inhibition" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inhibition</a> by <a href="https://mstdn.science/tags/MERS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MERS</a>-CoV Nsp1 reveals a conserved mechanism for <a href="https://mstdn.science/tags/betacoronaviruses" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#betacoronaviruses</a>, Cell Rep.: <a href="https://doi.org/10.1016/j.celrep.2023.113156" rel="nofollow noopener noreferrer" target="_blank">https://doi.org/10.1016/j.celrep.2023.113156</a> <a href="https://mstdn.science/tags/research" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#research</a> <a href="https://mstdn.science/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#science</a> <a href="https://mstdn.science/tags/merbecovirus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#merbecovirus</a>

Giuseppe Michieli<a href="https://mstdn.science/tags/Isolation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Isolation</a> and genetic <a href="https://mstdn.science/tags/characterization" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#characterization</a> of <a href="https://mstdn.science/tags/MERS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MERS</a>-CoV from dromedary <a href="https://mstdn.science/tags/camels" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#camels</a> in the <a href="https://mstdn.science/tags/UAE" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#UAE</a>, Front Vet Sci.: <a href="https://doi.org/10.3389/fvets.2023.1182165" rel="nofollow noopener noreferrer" target="_blank">https://doi.org/10.3389/fvets.2023.1182165</a> <a href="https://mstdn.science/tags/research" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#research</a> <a href="https://mstdn.science/tags/enzootic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#enzootic</a> <a href="https://mstdn.science/tags/zoonoses" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#zoonoses</a> <a href="https://mstdn.science/tags/betacoronavirus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#betacoronavirus</a> <a href="https://mstdn.science/tags/merbecovirus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#merbecovirus</a>

Giuseppe Michieli<a href="https://mstdn.science/tags/IL13" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#IL13</a> induced <a href="https://mstdn.science/tags/inflammation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inflammation</a> increases <a href="https://mstdn.science/tags/DPP4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#DPP4</a> abundance but does not enhance <a href="https://mstdn.science/tags/MERS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MERS</a>-CoV <a href="https://mstdn.science/tags/replication" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#replication</a> in <a href="https://mstdn.science/tags/airway" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#airway</a> epithelia <a href="https://pubmed.ncbi.nlm.nih.gov/37698016/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1TK-00Bd3YG_J75ZOCfC6LyGWkLBDpQrYdxjS3Imr6VqqZDQLu&fc=None&ff=20230912100253&v=2.17.9.post6+86293ac" rel="nofollow noopener noreferrer" target="_blank">https://pubmed.ncbi.nlm.nih.gov/37698016/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1TK-00Bd3YG_J75ZOCfC6LyGWkLBDpQrYdxjS3Imr6VqqZDQLu&fc=None&ff=20230912100253&v=2.17.9.post6+86293ac</a> <a href="https://mstdn.science/tags/research" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#research</a> <a href="https://mstdn.science/tags/EIDs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#EIDs</a> <a href="https://mstdn.science/tags/coronavirus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#coronavirus</a> <a href="https://mstdn.science/tags/merbecovirus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#merbecovirus</a>

Giuseppe MichieliMiddle East respiratory syndrome <a href="https://mstdn.science/tags/coronavirus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#coronavirus</a> (<a href="https://mstdn.science/tags/MERS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MERS</a>-CoV) - <a href="https://mstdn.science/tags/KSA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#KSA</a>: <a href="https://mstdn.science/tags/WHO" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#WHO</a> D.O.N.: <a href="https://www.who.int/emergencies/disease-outbreak-news/item/2023-DON484" rel="nofollow noopener noreferrer" target="_blank">https://www.who.int/emergencies/disease-outbreak-news/item/2023-DON484</a> <a href="https://mstdn.science/tags/zoonoses" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#zoonoses</a> <a href="https://mstdn.science/tags/EIDs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#EIDs</a> <a href="https://mstdn.science/tags/betacoronavirus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#betacoronavirus</a> <a href="https://mstdn.science/tags/merbecovirus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#merbecovirus</a> <a href="https://mstdn.science/tags/alert" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#alert</a>

Giuseppe Michieli''On 13 June, he was in <a href="https://mstdn.science/tags/critical" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#critical</a> condition and referred to an intensive care unit (<a href="https://mstdn.science/tags/ICU" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ICU</a>) at a specialized government tertiary hospital where he was put on mechanical <a href="https://mstdn.science/tags/ventilation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ventilation</a>. He deteriorated and a nasopharyngeal swab was collected on 21 June and tested positive for MERS-CoV by PCR on 23 June 2023.'' <a href="https://mstdn.science/tags/mers" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#mers</a> <a href="https://mstdn.science/tags/coronavirus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#coronavirus</a> <a href="https://mstdn.science/tags/betacoronavirus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#betacoronavirus</a> <a href="https://mstdn.science/tags/merbecovirus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#merbecovirus</a> <a href="https://mstdn.science/tags/UAE" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#UAE</a> <a href="https://mstdn.science/tags/alert" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#alert</a> <a href="https://mstdn.science/tags/surveillance" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#surveillance</a>

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