toad.social

0 posts0 participants0 posts today

CITO GreenhouseUnlocking the Secrets of the Mind and Body: A Journey into Interoception and Emotion<a href="https://mastodon.social/tags/MindBodyConnection" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MindBodyConnection</a> <a href="https://mastodon.social/tags/Interoception" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Interoception</a> <a href="https://mastodon.social/tags/BloodBrainBarrier" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#BloodBrainBarrier</a> <a href="https://mastodon.social/tags/Emotions" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Emotions</a> <a href="https://mastodon.social/tags/Nociception" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Nociception</a> <a href="https://mastodon.social/tags/Antinociception" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Antinociception</a> <a href="https://mastodon.social/tags/SelfAwareness" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#SelfAwareness</a> <a href="https://mastodon.social/tags/MentalHealth" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MentalHealth</a> <a href="https://mastodon.social/tags/Neuroscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Neuroscience</a> <a href="https://mastodon.social/tags/ExploreYourMind" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ExploreYourMind</a> <a href="https://mastodon.social/tags/BrainScience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#BrainScience</a> <a href="https://mastodon.social/tags/Mindfulness" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Mindfulness</a> <a href="https://mastodon.social/tags/EmotionalIntelligence" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#EmotionalIntelligence</a> <a href="https://mastodon.social/tags/ScienceExplained" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ScienceExplained</a> <a href="https://mastodon.social/tags/GeomagneticField" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#GeomagneticField</a><a href="https://youtube.com/shorts/bUaRkCnjZtg?feature=share" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://youtube.com/shorts/bUaRkCnjZtg?feature=share</a>

RhyothemisStudy offers a potential pathway for safer, non-addictive pain management<a href="https://www.news-medical.net/news/20241211/Study-offers-a-potential-pathway-for-safer-non-addictive-pain-management.aspx" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.news-medical.net/news/20241211/Study-offers-a-potential-pathway-for-safer-non-addictive-pain-management.aspx</a>"The study showed that when D₂O passed through the TRPV1 channel, it suppressed pain signal transmission and achieved effective analgesia."They studied both human cells in vitro and mice. This is good since another study found that D2O activated sweet taste receptors in humans, but not in mice - Sweet taste of heavy water <a href="https://www.nature.com/articles/s42003-021-01964-y" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.nature.com/articles/s42003-021-01964-y</a><a href="https://zeroes.ca/tags/HeavyWater" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#HeavyWater</a> <a href="https://zeroes.ca/tags/D2O" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#D2O</a> <a href="https://zeroes.ca/tags/solvents" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#solvents</a> <a href="https://zeroes.ca/tags/TRPchannels" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TRPchannels</a> <a href="https://zeroes.ca/tags/SweetTasteReceptors" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#SweetTasteReceptors</a> <a href="https://zeroes.ca/tags/Pain" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Pain</a> <a href="https://zeroes.ca/tags/nociception" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#nociception</a> <a href="https://zeroes.ca/tags/TRPV1" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TRPV1</a> <a href="https://zeroes.ca/tags/neuroscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neuroscience</a> <a href="https://zeroes.ca/tags/biology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#biology</a> <a href="https://zeroes.ca/tags/MouseVsHuman" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MouseVsHuman</a>

Albert CardonaPhD Position in Neural Mechanisms of Nociceptive Perception and Modulation, in the lab of Carlotta Martelli, Johannes Gutenberg University Mainz, Germany.To apply, write to Martelli directly, see below:<a href="https://mathstodon.xyz/tags/PhDPosition" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PhDPosition</a> <a href="https://mathstodon.xyz/tags/neuroscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neuroscience</a> <a href="https://mathstodon.xyz/tags/Drosophila" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Drosophila</a> <a href="https://mathstodon.xyz/tags/nociception" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#nociception</a>

RhyothemisUnderstanding the roots of chronic pain"A team of researchers led by Oscar Sánchez-Carranza in Professor Gary Lewin's lab at the Max Delbrück Center have identified a new function for the PIEZO2 protein -- in mediating chronic pain hypersensitivity. The research suggests a new target for analgesics and potentially explains why pain medications that target voltage gated sodium channels have been disappointing as clinical targets. "<a href="https://www.sciencedaily.com/releases/2024/07/240711111439.htm" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.sciencedaily.com/releases/2024/07/240711111439.htm</a><a href="https://zeroes.ca/tags/ChronicPain" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ChronicPain</a> <a href="https://zeroes.ca/tags/Piezo" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Piezo</a> <a href="https://zeroes.ca/tags/Piezo2" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Piezo2</a> <a href="https://zeroes.ca/tags/nociception" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#nociception</a> <a href="https://zeroes.ca/tags/neuroscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neuroscience</a> <a href="https://zeroes.ca/tags/fibromyalgia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#fibromyalgia</a>

RhyothemisDr. Jarred Younger, PhD will be doing a weekly YouTube series on the latest research on pain and chronic illnesses such as fibromyalgia, ME/CFS, Long Covid and Gulf War Syndrome.🙂 ❤️ <a href="https://youtu.be/ZWWM6duVScE?si=VSatnYUYwMlxlUQX" rel="nofollow noopener noreferrer" target="_blank">https://youtu.be/ZWWM6duVScE?si=VSatnYUYwMlxlUQX</a><a href="https://zeroes.ca/tags/fibromyalgia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#fibromyalgia</a> <a href="https://zeroes.ca/tags/ChronicPain" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ChronicPain</a> <a href="https://zeroes.ca/tags/MECFS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MECFS</a> <a href="https://zeroes.ca/tags/LongCovid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#LongCovid</a> <a href="https://zeroes.ca/tags/GulfWarSyndrome" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#GulfWarSyndrome</a> <a href="https://zeroes.ca/tags/GulfWarIllness" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#GulfWarIllness</a> <a href="https://zeroes.ca/tags/MCAS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MCAS</a> <a href="https://zeroes.ca/tags/AutoimmuneDiseases" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#AutoimmuneDiseases</a> <a href="https://zeroes.ca/tags/neuroinflammation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neuroinflammation</a> <a href="https://zeroes.ca/tags/nociception" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#nociception</a> <a href="https://zeroes.ca/tags/Pain" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Pain</a> <a href="https://zeroes.ca/tags/inflammation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inflammation</a>

RhyothemisI finally took a picture of my hand after washing in warm water. The turning-red thing has been going on for a couple of years and it was much worse when it first started - but I could never remember to take a picture back then. I get a bit more brain-foggy than usual when it happens. I think it's erythromelalgia. It used to burn and hurt, but not much, if at all, these days. My feet used to do it, too - either triggered by taking a hot shower or when working in the heat outdoors. That doesn't happen anymore. Maybe the low dose naltrexone helped, or maybe it was just time.I got the LDN Rx online after reading this case report. The patient had worse symptoms than me (1). I asked for the LDN based on other chronic pain and eczema, since I had diagnoses for those and they are recognized indications for LDN.I noticed her 2nd and 3rd toes are a bit fused, like mine. Not quite syndactyly. There's another case report on a baby boy with an SCN9A/Nav1.7 mutation who had 2nd and 3rd toe syndactyly along with pain insensitivity. His mother also had the mutation and 2nd and 3rd toe syndactyly, but she had pain hypersensitivity. I have wondered about the difference in phenotype being due to sex differences.Under 'Treatment' in the 2nd case report, naloxone is discussed as a possibility, but no information is given as to whether the patient was given naloxone or his response.1 - <a href="https://doi.org/10.25251/skin.4.3.15" rel="nofollow noopener noreferrer" target="_blank">https://doi.org/10.25251/skin.4.3.15</a>2 - CW: there are disturbing pictures in this article of injuries to the baby boy's hands caused by him chewing on them. <a href="https://pubmed.ncbi.nlm.nih.gov/30834170/" rel="nofollow noopener noreferrer" target="_blank">https://pubmed.ncbi.nlm.nih.gov/30834170/</a><a href="https://zeroes.ca/tags/erythromelalgia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#erythromelalgia</a> <a href="https://zeroes.ca/tags/pain" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#pain</a> <a href="https://zeroes.ca/tags/LowDoseNaltrexone" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#LowDoseNaltrexone</a> <a href="https://zeroes.ca/tags/SCN9A" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#SCN9A</a> <a href="https://zeroes.ca/tags/nociception" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#nociception</a> <a href="https://zeroes.ca/tags/SodiumChannels" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#SodiumChannels</a>

Rhyothemison my to-read list:Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function <a href="https://doi.org/10.1038/s41467-023-37963-2" rel="nofollow noopener noreferrer" target="_blank">https://doi.org/10.1038/s41467-023-37963-2</a><a href="https://zeroes.ca/tags/Pain" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Pain</a> <a href="https://zeroes.ca/tags/gympietides" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#gympietides</a> <a href="https://zeroes.ca/tags/nociception" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#nociception</a> <a href="https://zeroes.ca/tags/SodiumChannels" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#SodiumChannels</a> <a href="https://zeroes.ca/tags/TMEMchannels" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TMEMchannels</a> <a href="https://zeroes.ca/tags/NaturalProducts" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#NaturalProducts</a>

RhyothemisAnimalogic put out an interesting Floralogic episode on the extreme, long-lasting pain caused by gympie gympie - a plant in the same family as stinging nettle - Gympie Gympie Is Doing Everything It Can To Ruin Your Life <a href="https://youtu.be/kIGQYE8pH_Y?si=4QN-DzBHdRg3OEen" rel="nofollow noopener noreferrer" target="_blank">https://youtu.be/kIGQYE8pH_Y?si=4QN-DzBHdRg3OEen</a>It's an Australian plant, of course."Altering the activation threshold, combined with effects upon inactivation, likely leads to nociceptor activation and the sensation of pain, akin to biophysical changes observed in painful conditions associated with NaV1.7 [SCN9A] gain-of-function mutations such as inherited erythromelalgia (IEM) and paroxysmal extreme pain disorder (PEPD), respectively ... As the gympietides bear little similarity to any other known NaV modulators and display unusual effects particularly on NaV inactivation, it is difficult to predict possible binding sites at this point. However, based on activity of animal venom–derived toxins and the biophysics of NaV gating, the extracellular loops of the domain IV voltage sensor could be a possible binding site." <a href="https://doi.org/10.1126/sciadv.abb8828" rel="nofollow noopener noreferrer" target="_blank">https://doi.org/10.1126/sciadv.abb8828</a><a href="https://zeroes.ca/tags/Pain" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Pain</a> <a href="https://zeroes.ca/tags/nociception" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#nociception</a> <a href="https://zeroes.ca/tags/NaturalProducts" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#NaturalProducts</a> <a href="https://zeroes.ca/tags/erythromelalgia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#erythromelalgia</a> <a href="https://zeroes.ca/tags/gympietides" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#gympietides</a> <a href="https://zeroes.ca/tags/SodiumChannels" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#SodiumChannels</a> <a href="https://zeroes.ca/tags/SCN9A" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#SCN9A</a>

Albert Cardona<a href="https://botsin.space/@flypapers" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@flypapers</a>Dissecting neural circuits for cold nociception in the <a href="https://mathstodon.xyz/tags/Drosophila" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Drosophila</a> larva, by Atit Patel in D. Cox lab: <a href="http://biorxiv.org/content/10.1101/2023.07.31.551339v1" rel="nofollow noopener noreferrer" target="_blank">http://biorxiv.org/content/10.1101/2023.07.31.551339v1</a>Atit was a visitor of my former lab at <a href="https://mathstodon.xyz/tags/HHMIJanelia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#HHMIJanelia</a>. Took years to map the circuit, identify GAL4 lines, design and run behavioral assays and make sense of it all. Atit, a PhD student, did all the mapping and all the experiments and wrote most of the paper, and did a great job at it.For the insiders: this is about class III md (multidendritic) somatosensory neurons in the fly larva, and their synaptic connectivity, primarily onto various Basin neurons (Ohyama, Schneider-Mizell et al. 2015 <a href="https://www.nature.com/articles/nature14297" rel="nofollow noopener noreferrer" target="_blank">https://www.nature.com/articles/nature14297</a> , Jovanic, Schneider-Mizell et al. et al. 2016 <a href="https://www.sciencedirect.com/science/article/pii/S0092867416312429" rel="nofollow noopener noreferrer" target="_blank">https://www.sciencedirect.com/science/article/pii/S0092867416312429</a> ) but also other neurons such as Down-and-Back (Burgos et al. 2018 <a href="https://elifesciences.org/articles/26016" rel="nofollow noopener noreferrer" target="_blank">https://elifesciences.org/articles/26016</a> ) and PNs of the class IV mds (Gerhard et al. 2017 <a href="https://elifesciences.org/articles/29089" rel="nofollow noopener noreferrer" target="_blank">https://elifesciences.org/articles/29089</a> ).In other words, how somatosensoty neurons for cold nociception (class III mds) feed into the local circuits that process nociception (class IV mds) and mechanoreception (chordotonals).Note this work is unrelated to how the larva senses and responds to cold and warm stimuli (Hernandez-Nunez et al. 2021 <a href="https://www.science.org/doi/abs/10.1126/sciadv.abg6707" rel="nofollow noopener noreferrer" target="_blank">https://www.science.org/doi/abs/10.1126/sciadv.abg6707</a> )<a href="https://mathstodon.xyz/tags/neuroscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neuroscience</a> <a href="https://mathstodon.xyz/tags/nociception" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#nociception</a> <a href="https://mathstodon.xyz/tags/connectomics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#connectomics</a>

Recent searches

Search options

Administered by:

Server stats:

#nociception