Paul Houle<p>🐍 Where did RNA come from? Origin-of-life scientists help to answer the question</p><p><a href="https://phys.org/news/2025-07-rna-life-scientists.html" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">phys.org/news/2025-07-rna-life</span><span class="invisible">-scientists.html</span></a></p><p><a href="https://mastodon.social/tags/rna" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>rna</span></a> <a href="https://mastodon.social/tags/molbio" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>molbio</span></a> <a href="https://mastodon.social/tags/biology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>biology</span></a> <a href="https://mastodon.social/tags/life" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>life</span></a> <a href="https://mastodon.social/tags/chemistry" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>chemistry</span></a> <a href="https://mastodon.social/tags/research" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>research</span></a></p>
Administered by:
#rna
5 posts5 participants0 posts today
https://www.europesays.com/uk/257014/ New discovery uncovers hidden drivers of DNA transcription errors #Bases #Cancer #Cell #DNA #Gene #Genes #Genetic #Genetics #Nucleotide #Nucleotides #Protein #Research #rna #Science #Transcription #UK #UnitedKingdom
United Kingdom · New discovery uncovers hidden drivers of DNA transcription errors - United KingdomEvery living cell must interpret its genetic code - a sequence of chemical letters that governs countless cellular functions. A new study by researchers from
mRNA 3′UTRs chaperone intrinsically disordered regions to control protein activity.
#RNA #mRNA #3UTR #IntrinsicallyDisorderedRegions #IDRs #IntrinsicallyDisorderedProteins #Chaperones #Preprint
bioRxiv · mRNA 3′UTRs chaperone intrinsically disordered regions to control protein activityMore than 2,700 human mRNA 3′UTRs have hundreds of highly conserved (HC) nucleotides, but their biological roles are unclear. Here, we show that mRNAs with HC 3′UTRs mostly encode proteins with long intrinsically disordered regions (IDRs), including MYC, UTX, and JMJD3. These proteins are only fully active when translated from mRNA templates that include their 3′UTRs, raising the possibility of functional interactions between 3′UTRs and IDRs. Rather than affecting protein abundance or localization, we find that HC 3′UTRs control transcriptional or histone demethylase activity through co-translationally determined protein oligomerization states that are kinetically stable. 3′UTR-dependent changes in protein folding require mRNA-IDR interactions, suggesting that mRNAs act as IDR chaperones. These mRNAs are multivalent, a biophysical RNA feature that enables their translation in network-like condensates, which provide favorable folding environments for proteins with long IDRs. These data indicate that the coding sequence is insufficient for the biogenesis of biologically active conformations of IDR-containing proteins and that RNA can catalyze protein folding.
### Competing Interest Statement
The authors have declared no competing interest.
Pershing Square Foundation, https://ror.org/04tce9s05
G. Harold & Leila Y. Mathers Foundation
National Institutes of Health, DP1GM123454, R35GM144046
Memorial Sloan Kettering Cancer Center, https://ror.org/02yrq0923, P30 CA008748
Turns out RNA can make a GNRA tetraloop-like motif out of almost anything! Like in these pentaloops, whose looped-out bases interact with proteins.
Read the preprint:
https://biorxiv.org/content/10.1101/2025.07.03.663028v1
Bio-On-Magnetic-Beads (BOMB): #OpenSource platform for high-throughput #nucleic acid #extraction & manipulation:
-synthesis of functionalised #MagneticBeads
-HT #purification of #RNA & #DNA from a range of #bacterial, #animal, #plant, #environmental & #synthetic sources
-bead-based protocol for #bisulfite conversion & size selection of DNA & RNA fragments
Article: https://doi.org/10.1371/journal.pbio.3000107
Web: https://bomb.bio/
#DIYbio #DIYchem #chemistry #magnetic #lab #instruments
Want to learn more about the Religious Naturalist view? Watch a live streamed presentation June 26th at 10:30 a.m. PDT/ 1:30 p.m. EDT from the Star Island Conference of the Institute on Religion in an Age of Science.
#ReligiousNaturalism #ReligiousNaturalist #RNA #IRAS #StarIsland #Nature
#HiringAlert
Looking to tackle computational challenges of RNA folding and binding? Come build new RNA algorithms as a #postdoc in my lab!
More info: https://euraxess.ec.europa.eu/jobs/350755
https://www.europesays.com/uk/195232/ Yale researchers triple precision and efficiency in genome editing #Bases #Cancer #Cas9 #Cell #crispr #DevelopmentalBiology #DNA #Gene #Genetic #Genetics #Genome #GenomeEditing #Protein #rna #Science #Technology #UK #UnitedKingdom
Unser Heft 6/2025 ist raus!
Titelthema: Gibt es das #PostVAC-Syndrom?
Außerdem:
- #BrainGain aus den USA?;
- #Nachhaltigkeit im Lab;
- #Archaeen;
- #Zellbiologie
- #RNA-Bibliotheken;
- Therapeutische #Viren;
- #Protein-Labeling;
- …
Das ganze Heft online: https://www.laborjournal.de/rubric/aktuell/index.php
https://www.europesays.com/uk/181439/ Mapping genetic activity offers new clues for personalized cancer treatment #brain #BrainCancer #Cancer #Cell #diabetes #DNA #Genes #Genetic #Genetics #Genome #Genomic #Gliomas #Medicine #oxygen #pH #PrecisionMedicine #Protein #Research #rna #Science #Transcriptomics #Tumor #UK #UnitedKingdom