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#SARS2

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Imagine a faith that puts the well-being of people ahead of corporate interests in 2025.

stmargaretscedarcottage.ca/why

THIS is what living a moral life can look like. Caring about others, refusing to perpetuate false narratives, protecting oneself, following evidence as it accumulates.

BONUS: THIS WEEK they're selling ultra-quiet air purifiers at a discount, to fundraise stmargaretscedarcottage.ca/ord

h/t a zero :mastomask: 👍

ST. MARGARET 'S CEDAR COTTAGE ANGLICAN CHURCHWhy are we still masking?Some people might wonder why St. Margaret’s continues to take precautions against the spread of Covid in our community when it feels like the rest of the world has moved on. Our decision may make...

This paper nature.com/articles/s42255-025 is interesting. They tested Vitamin B3 in a pill that is

designed to release nicotinamide [a form of Vitamin B3] in the lower small intestine and colon

And found:

1️⃣ Acute COVID-19 might be safely and easily reduced in severity and duration
2️⃣ In general, no improvement in Long COVID rates (here termed Post-COVID syndrome, PCS)
3️⃣ BUT, for people with recovery-like trajectories, they found superior outcomes. This takes a few quotes:

The subgroup was

participants at risk who had shown improvement in the primary endpoint or one of the three key secondary endpoints in the acute phase of the disease

In [this] subgroup, a significant benefit of nicotinamide was also observed in participants with PCS (nicotinamide: n = 48, PCS score 8.33 ± 0.84; placebo: n = 57, PCS score 11.82 ± 1.03; absolute difference: −3.49; 95% confidence interval, −6.1 to −0.86; P = 0.010

Now we all know how Long COVID isn't one single disease. Let's assume for a second that other results that suggest at least one subset has a microbiome component are correct.

As they say "life finds a way" so it would make sense that remnant gut populations could rebound over time and that this subset of LC sufferers might be more likely to have recovery trajectories. (This while we have no treatments for any subset.)

This obviously won't stop the pandemic nor its consequences, but still, here's hoping that there's no patent encumbrance on coating B3 for lower-gut delivery.

Of course here in BC we'll get access the same time we get access to Metformin. ⌛

h/t zeroes.ca/explore I think?

NatureNicotinamide modulates gut microbial metabolic potential and accelerates recovery in mild-to-moderate COVID-19 - Nature MetabolismIn a prospective, double-blind, randomized, placebo-controlled trial, supplementation with a combination of conventional and gut-targeted nicotinamide was safe and effective in ameliorating COVID-19 symptoms.
Continued thread

Updated #CDC estimates show we'd pretty much been in a JN.1.11 soup since Dec, until late March, when LP.8.1 took majority.

Data collection continues to be low priority nationally—as exactly zero regions have enough data for CDC to plot.

CDC breaks out recombinant XFC from FLiRT parent LF.7 . (Our dataviz now identifies parentage for each recombinant.) Raj's dashboard was last updated today.

#ThisIsOurPolio #Covid #Covid19 #SARS2 #variants #CovidIsNotOver #CovidIsAirborne #dataviz #datavis

Continued thread

Updated #CDC estimates show we'd pretty much been in a JN.1.11 soup since Dec, until late March, when LP.8.1 took majority.

Data collection continues to be a low priority nationally, as exactly zero regions have enough data for CDC to plot.

Two children of LF.7.7, dot1 and dot2, broken out by CDC, together with PA.1, a grandchild of MC.10.

Raj's dashboard was last updated a week ago today.

#ThisIsOurPolio #Covid #Covid19 #SARS2 #variants #CovidIsNotOver #CovidIsAirborne #dataviz #datavis

Continued thread

Updated #CDC estimates show we've pretty much been in a JN.1.11 soup since Dec, until late March, when LP.8.1 took majority.

Data collection continues to be a low priority nationally, as exactly zero regions have enough data for CDC to plot.

No new variants broken out, yet CDC seems to have resources to tailor their color key: hcommons.social/@beadsland/114

Raj's dashboard was updated on today.

#ThisIsOurPolio #Covid #Covid19 #SARS2 #variants #CovidIsNotOver #CovidIsAirborne #dataviz #datavis

Replied in thread

@DenisCOVIDinfoguy they also cite pubmed.ncbi.nlm.nih.gov/358102

which has this absolute adjective of a hypothesis:

SARS-CoV-2 may bind to ACE2 in order to enter the host brainstem cell and change baroreflex sensitivity

because

The integral parts of the brain renin-angiotensin system, as ACE2 enzyme, are highly expressed in the brainstem, which may also be involved in baroreflex sensitivity, playing an important role in HRV.

which would help explain POTS!!

PubMedPotential autonomic nervous system dysfunction in COVID-19 patients detected by heart rate variability is a sign of SARS-CoV-2 neurotropic features - PubMedIncreasing evidence strongly support that the newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to the development of COVID-19-associated central nervous system (CNS) manifestations. The presence of SARS-CoV-2 viral protein in the brainstem, which includes cardiovas …
Continued thread

Updated #CDC estimates show we've pretty much been in a JN.1.11 soup since Dec, until late March, when LP.8.1 took majority.

Data collection continues to be a low priority nationally, as only one region (NY/NJ) has enough data for CDC to plot.

No new variants broken out, yet CDC seems to have resources to tailor their color key: hcommons.social/@beadsland/114

Raj's dashboard was updated on Sunday.

#ThisIsOurPolio #Covid #Covid19 #SARS2 #variants #CovidIsNotOver #CovidIsAirborne #dataviz #datavis

Continued thread

Second time #CDC has reported estimates for more than two regions at a time since October.

To be clear, national data used for chart above are modeled on regional data collection.

LP.8.1 now estimated at majority in Great Lakes, nearing majority in NY/NJ and Mid-Atlantic.

XEC (incl. XEC.4) still around a quarter share in all three regions.

[For color key, see: covid.cdc.gov/covid-data-track]

#ThisIsOurPolio #Covid #Covid19 #SARS2 #variants #CovidIsNotOver #CovidIsAirborne #WearAMask #BetterMasks

Continued thread

A FLuQE wavelet opened September, cresting as KP.3.1.1 / MC wave into November. FDA's second-guess vaccine target, KP.2, dropped out in December. Updated #CDC estimates indicate we've been in a JN.1.11 soup pretty much since then.

No new variants broken out by CDC, as KP.1.1.3 / LP descendant LP.8.1 approaches majority.

No recent GISAID data—as Raj's dashboard hasn't updated in near a month.

#ThisIsOurPolio #Covid #Covid19 #SARS2 #variants #CovidIsNotOver #CovidIsAirborne #dataviz #datavis

"57% decreased odds of 1 or more PCC symptoms and a 73% decreased odds of 2 or more PCC symptoms" - that's dramatically lower odds of a child suffering:

➡️ unable to remember
➡️ unable to focus
➡️ unable to exercise
➡️ headache
➡️ insomnia
➡️ lightheadedness, fainting
➡️ extreme fatigue
➡️ loss of vivacity, joie de vivre
➡️ personality changes
➡️ hospitalization and death

Protect your children.

Otherwise, if they survive, they will wonder why you didn't protect them, when it costs only the time to get vaccinated, and a few pennies a day N95s and HEPA filters.

Otherwise, you might find yourself mourning the potential you KNEW your child had, and desperately hoping for treatments.

Treatments may never come. Neurons don't come back. Developmental windows close.

Don't be the ghoul that condemns your children, don't strip their future because it's not cool to mask. It might not be cool to wear a bike helmet either. Concussions can't be undone, either. Don't usher your children willingly into suffering and disability.

DON'T FUCKING STACK THE ODDS AGAINST YOUR KIDS.

pmc.ncbi.nlm.nih.gov/articles/

ht/ @augieray mastodon.social/@augieray/1141

PubMed Central (PMC)COVID-19 Vaccination and Odds of Post–COVID-19 Condition Symptoms in Children Aged 5 to 17 YearsDoes COVID-19 mRNA vaccination reduce the occurrence of post–COVID-19 condition (PCC) following SARS-CoV-2 infection in children aged 5 to 17 years? In this case-control study with 622 participants, vaccination was associated with a 57% decreased ...
Replied in thread

@Chaotica Nicht zu vergessen die zu oft direkte Wirkung auf das Gehirn, die regelrechte Zerstörung der Fähigkeit der Risiko-Gefahren-Abschätzung durch #Sars2 im FrontalCortex - was sicher mit dazu beigetragen hat, dass sogar gesellschaftlich die Gesundheitsfürsorge des Pandemie-Endemie-Schutzes eingestellt bis sogar bekämpft wurde und wird.

Dass dann mit zerstörter Risiko-Gefahren-Wahrnehmung+Urteilsfähigkeit auch die Empathie-Fähigkeit - welche durchaus damit zusammenhängt - mit draufgeht ...

Continued thread

#CDC has long time now been piloting the craft of #PublicHealth sans navigational equipment.

To be clear, national data used for chart above are modeled on regional data collection.

Given little data we do have, LP.8.1 now estimated as nearing majority status in NY/NJ, with XEC (incl. XEC.4) still near a third share.

As for other regions?

[For color key, see: covid.cdc.gov/covid-data-track]

#ThisIsOurPolio #Covid #Covid19 #SARS2 #variants #CovidIsNotOver #CovidIsAirborne #WearAMask #BetterMasks

Continued thread

After January's FLiRT soup (JN.1 and JN.1.11 lineages vying for dominance), we've returned to JN.1.11 soup (FLiRT and FLuQE clusters competing), that began when FLuQE majority ended in November.

#CDC breaks out a new FLuQE variant, MC.28.1, even as being squeezed by LP.8.1 fam.

Raj updated global dashboard Sunday, incl. hundreds of U.S. samples early Feb. Still await updated U.S. dashboard.

#ThisIsOurPolio #Covid #Covid19 #SARS2 #variants #CovidIsNotOver #CovidIsAirborne #dataviz #datavis

Continued thread

Updated GISAID data for late January has FluQE31 KP.3.1.1 / MC and children down to just over a fifth of all sequences.

FLiRT KS.1.1 / FLuQE KP.3.3 hybrid XEC down near two fifths.

LP.8.1 and child LP.8.1.1 / NY together already another fifth.

Meanwhile, in remaining fifth:
• JN.1 FLiRT descendant LF.7 remains diverse despite pressure; and
• XEQ (recombinant of FLiRT KS.1.1.2 and KP.3) continues to stand out.

#ThisIsOurPolio #Covid #Covid19 #SARS2 #variants #CovidIsNotOver #CovidIsAirborne

Continued thread

#CDC has long time now been piloting the craft of #PublicHealth sans navigational equipment.

To be clear, national data used for chart above are modeled on regional data collection.

Given little data we do have, LP.8.1 has gained plurality status in NY/NJ and Great Lakes regions, XEC still majority in Mtn/Dakotas, with cousin XEQ prominent.

[For color key, see: covid.cdc.gov/covid-data-track]

#ThisIsOurPolio #Covid #Covid19 #SARS2 #variants #CovidIsNotOver #CovidIsAirborne #WearAMask #BetterMasks

Continued thread

After January's FLiRT soup (JN.1 and JN.1.11 lineages vying for dominance), we've returned to JN.1.11 soup (FLiRT and FLuQE clusters competing), that began when FLuQE majority ended in November.

After no data two weeks ago, #CDC updated variant estimates.

Raj has updated dashboard Sunday with new GISAID sequences. As of data two weeks ago, XEC.8 joins XEC.2 and LP.8.1.1 / NY as significant.

#ThisIsOurPolio #Covid #Covid19 #SARS2 #variants #CovidIsNotOver #CovidIsAirborne #dataviz #datavis