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Scientific FrontlineScientists at Harvard Medical School have discovered a distinct population of <a href="https://mastodon.social/tags/Tregs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Tregs</a> dwelling in the protective layers of the <a href="https://mastodon.social/tags/brains" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#brains</a> of healthy mice with a repertoire much broader than inflammation control. <a href="https://mastodon.social/tags/Biology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Biology</a> <a href="https://mastodon.social/tags/Biomedical" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Biomedical</a> <a href="https://mastodon.social/tags/Neuroscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Neuroscience</a> <a href="https://mastodon.social/tags/sflorg" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#sflorg</a> <a href="https://www.sflorg.com/2025/01/bio01282501.html" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.sflorg.com/2025/01/bio01282501.html</a>

David Usharauli1/ Let's do a deep dive into the best research article on Foxp3+ Tregs this month (January 2025) and highlight its strengths and weaknesses. <a href="https://bookstodon.com/tags/immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immunology</a> <a href="https://bookstodon.com/tags/Tregs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Tregs</a> <a href="https://bookstodon.com/tags/allergy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#allergy</a> <a href="https://bookstodon.com/tags/microbiota" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#microbiota</a> <a href="https://bookstodon.com/tags/microbiome" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#microbiome</a> <a href="https://bookstodon.com/tags/Foxp3" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Foxp3</a> <a href="https://www.nature.com/articles/s41586-024-08440-7" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.nature.com/articles/s41586-024-08440-7</a>

Thiago Carvalho'We have previously demonstrated that excising transcription factor Kruppel-like factor 2 (Klf2) within the T cell lineage blocks the generation of peripheral-derived Tregs (pTregs) without impairing production of thymic-derived Tregs. Using this mouse model, we have now demonstrated that eliminating pTregs is sufficient to delay/prevent tumor malignancy without causing autoimmunity.' <a href="https://qoto.org/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunology</a> <a href="https://qoto.org/tags/TumorImmunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TumorImmunology</a> <a href="https://qoto.org/tags/Tregs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Tregs</a> <a href="https://qoto.org/tags/Immunotherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunotherapy</a> <a href="https://www.pnas.org/doi/10.1073/pnas.2404916121" rel="nofollow noopener noreferrer" target="_blank">https://www.pnas.org/doi/10.1073/pnas.2404916121</a>

Chuck Darwin“It’s difficult to think of a disease, injury or injection that doesn’t involve some kind of <a href="https://c.im/tags/immune" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immune</a> <a href="https://c.im/tags/response" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#response</a>, and our finding really changes the way we could control this response,” said Professor Adrian Liston from the University’s Department of Pathology and the study’s corresponding author. “We’ve uncovered new rules of the immune system. This ‘unified healer army’ can do everything – repair injured muscle, make your fat cells respond better to insulin, regrow hair follicles. To think that we could use it in such an enormous range of diseases is fantastic: it’s got the potential to be used for almost everything.”Lymphoid organs are integral parts of the immune system, responsible for producing <a href="https://c.im/tags/lymphocytes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#lymphocytes</a>, a type of white blood cell that includes T cells. T cells begin life in the bone marrow and then move to the thymus, an organ in the upper mid-chest, where they mature into specialized subsets, including <a href="https://c.im/tags/Tregs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Tregs</a>. Once fully matured, T cells are exported to peripheral lymphatic tissues and organs like the spleen, tonsils, and lymph nodes (some move to the bloodstream). It was thought that’s where Tregs stayed, on ‘standby’ until called upon by the immune system.To test this, the researchers analyzed the Tregs present in 48 different tissues in mice, including lymphoid and non-lymphoid tissues and tissues associated with the gut. They found them in all tissue types, suggesting that Tregs weren’t specialized cell populations confined to lymphoid tissues but moved around the body, executing repair functions in areas that need it.“Now that we know these regulatory T cells are present everywhere in the body, in principle ⭐️we can start to make immune suppression and tissue regeneration treatments that are targeted against a single organ⭐️ – a vast improvement on current treatments that are like hitting the body with a sledgehammer,” Liston said <a href="https://newatlas.com/medical/regulatory-t-cells-discovery/" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://newatlas.com/medical/regulatory-t-cells-discovery/</a>

Thiago Carvalho'Here, our goal is to review distinct domains of Treg function in the host response to respiratory infection and subsequent lung injury and discuss open questions in the field that should be addressed as Treg-based therapeutics move into translation.' <a href="https://qoto.org/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunology</a> <a href="https://qoto.org/tags/tregs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#tregs</a> <a href="https://www.jci.org/articles/view/170505" rel="nofollow noopener noreferrer" target="_blank">https://www.jci.org/articles/view/170505</a>

Seth Thomas ScanlonAlso in <a href="https://sciencemastodon.com/@sciencemagazine" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@sciencemagazine</a> this week: Giuseppe Matarese pens a Perspective on the link between <a href="https://mstdn.social/tags/obesity" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#obesity</a> and <a href="https://mstdn.social/tags/autoimmunity" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#autoimmunity</a>! <a href="https://bit.ly/Sci_ade0113" rel="nofollow noopener noreferrer" target="_blank">https://bit.ly/Sci_ade0113</a><a href="https://mstdn.social/tags/immunometabolism" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immunometabolism</a> <a href="https://mstdn.social/tags/overnutrition" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#overnutrition</a> <a href="https://mstdn.social/tags/T1D" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#T1D</a> <a href="https://mstdn.social/tags/MS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MS</a> <a href="https://mstdn.social/tags/Tregs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Tregs</a> <a href="https://mstdn.social/tags/adipocytes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#adipocytes</a> <a href="https://mstdn.social/tags/CaloricRestriction" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CaloricRestriction</a> <a href="https://mstdn.social/tags/immunotherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immunotherapy</a>

Thiago Carvalho"We observed increased TGFβ-mediated induction of FoxP3+ cells in the presence of extracellular lactic acid, in a glycolysis-independent, acidity-dependent manner."<a href="https://qoto.org/tags/immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immunology</a> <a href="https://qoto.org/tags/Metabolism" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Metabolism</a> <a href="https://qoto.org/tags/Tregs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Tregs</a><a href="https://www.nature.com/articles/s41579-022-00837-3?utm_source=nrmicro_etoc&utm_medium=email&utm_campaign=toc_41579_21_3&utm_content=20230216" rel="nofollow noopener noreferrer" target="_blank">https://www.nature.com/articles/s41579-022-00837-3?utm_source=nrmicro_etoc&utm_medium=email&utm_campaign=toc_41579_21_3&utm_content=20230216</a>

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