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#bacteriophages

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michael

2-Apr-2025
The first case of #phageTherapy for biliary tract infection caused by #superbugs

eurekalert.org/news-releases/1 #science #medicine #microbiology #bacteriophages

EurekAlert!The first case of phage therapy for biliary tract infection caused by superbugs!Biliary tract infections (BTI), often linked to structural abnormalities like bile duct stones, pose significant treatment challenges due to drug-resistant bacteria like Pseudomonas aeruginosa. Phage therapy, which uses viruses to target bacteria, has emerged as a promising solution. This study by researchers from Fudan University and Army Medical University, published in hLife, reported the first successful use of personalized phage therapy for chronic BTI caused by multidrug-resistant P. aeruginosa. An 88-year-old patent with recurrent infections underwent phage therapy after traditional treatments failed. A customized phage cocktail was administered, leading to symptom improvement and reduced bacterial load. However, phage-resistant strains emerged, prompting a second round of therapy with a different phage, which further alleviated symptoms. Genomic analysis revealed bacterial mutations contributing to resistance. This study highlights the potential of phage therapy for treating drug-resistant infections, though challenges like bacterial heterogeneity and biofilm formation remain. Future research aims to optimize phage therapy strategies for better outcomes.
Public
Soh Kam Yung

"A century-old treatment that uses viruses to attack bacteria was successfully used in 2024 to save the life of a Singapore General Hospital (SGH) patient who had exhausted all care options for an antibiotic-resistant infection.

This made her the first patient in South-east Asia to benefit from phage therapy"

straitstimes.com/singapore/hea

#Bacteriophages#Health#Medicine
Public
Science Updates

"Knowing how more than one kind of phage can survive over time on a single bacterium could help in designing next-generation phage cocktails," said Nora Pyenson, PhD. "For example, each phage species might attack the bacterium in a different part of its lifecycle, enabling the whole population to be killed before resistance to the treatment evolves."

#bacteriophages #bacteria #microbiology #virus #virology #CellBiology #biology #naure #science #research

labroots.com/trending/microbio

LabrootsResearchers Reveal One Bacterium Can Play Host to Many Phages | MicrobiologySome viruses only infect bacterial cells; they are known as bacteriophages, and they have real potential to defeat antibiotic resistant superbugs. | Microbiology
Public
michael

11-JUL-2024
Researchers develop a way to make lifesaving #phages accessible, transportable and much easier to use
When #antibiotics fail, #bacteriophages can often save lives, but determining which ones will work and sourcing them is haphazard

eurekalert.org/news-releases/1
#science #PhageTherapy #bacteria #MicrobialEcology #medicine

EurekAlert!Researchers develop a way to make lifesaving phages accessible, transportable and much easier to useResearchers have developed a simple way to bring bacteriophage therapy into much closer reach for clinicians struggling to save patients with antimicrobial-resistant infections. The technology makes it possible to sort through hundreds or even thousands of phages in less than two hours to identify which will respond to a particular infection.  
Public
Lukas VFN 🇪🇺

How #polyps of the moon #jellyfish repel viral attacks on their microbiome
phys.org/news/2024-04-polyps-m

Marine #bacteriophages disturb the associated #microbiota of A. aurita with a recoverable effect on host morphology: Melissa Stante et al. frontiersin.org/journals/micro

"In the polyp stage, they are attached to the seabed and use their tentacles to catch food from the water. On their surface are numerous #bacteria that form the #microbiome, which plays an important role in the fitness of the polyp"

Polyp - an invertebrate animal with many tentacles
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