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JADe (he, him)Abajo en español...ENG: The Benefits of Daily Cannabis for the Middle-Aged Brain. Chronic low-dose oral or inhaled cannabis may improve working memory. By Gary Wenk Ph D. Published June 29, 2025 in PSYCHOLOGY TODAY<a href="https://www.psychologytoday.com/us/blog/your-brain-on-food/202506/the-benefits-of-daily-cannabis-for-the-middle-aged-brain" rel="nofollow noopener" translate="no" target="_blank">https://www.psychologytoday.com/us/blog/your-brain-on-food/202506/the-benefits-of-daily-cannabis-for-the-middle-aged-brain</a>ESP: "¿Por qué puede ser beneficioso el cannabis en la edad madura? Durante el envejecimiento normal, el número de receptores cannabinoides endógenos disminuye. La pérdida de estos receptores cannabinoides se correlaciona con un mayor nivel de inflamación en varias regiones cerebrales y pérdida de neuronas en el hipocampo.Esto es importante porque el hipocampo es fundamental para el aprendizaje y la memoria. La pérdida de receptores cannabinoides puede contribuir a las alteraciones de la memoria asociadas a edad avanzada.Estudios realizados en mi laboratorio han demostrado que la estimulación diaria de los receptores cannabinoides disminuía la inflamación cerebral y aumentaba significativamente la neurogénesis hipocampal en cerebros viejos. Estos cambios se asociaron a una mejora del aprendizaje y la memoria. Estos resultados indican que los beneficios potenciales del cannabis para el cerebro envejecido están probablemente relacionados con la reducción de la neuroinflamación regional y la estimulación de los receptores cannabinoides disponibles en las células madre latentes."<a href="https://mastodon.cr/tags/cannabis" class="mention hashtag" rel="nofollow noopener" target="_blank">#cannabis</a> <a href="https://mastodon.cr/tags/thc" class="mention hashtag" rel="nofollow noopener" target="_blank">#thc</a> <a href="https://mastodon.cr/tags/cbd" class="mention hashtag" rel="nofollow noopener" target="_blank">#cbd</a> <a href="https://mastodon.cr/tags/marijuana" class="mention hashtag" rel="nofollow noopener" target="_blank">#marijuana</a> <a href="https://mastodon.cr/tags/cannabismedicinal" class="mention hashtag" rel="nofollow noopener" target="_blank">#cannabismedicinal</a> <a href="https://mastodon.cr/tags/aginggracefully" class="mention hashtag" rel="nofollow noopener" target="_blank">#aginggracefully</a> <a href="https://mastodon.cr/tags/aging_geriatrics" class="mention hashtag" rel="nofollow noopener" target="_blank">#aging_geriatrics</a> <a href="https://mastodon.cr/tags/aginggratefully" class="mention hashtag" rel="nofollow noopener" target="_blank">#aginggratefully</a> <a href="https://mastodon.cr/tags/aging" class="mention hashtag" rel="nofollow noopener" target="_blank">#aging</a> <a href="https://mastodon.cr/tags/EfectoS%C3%A9quito" class="mention hashtag" rel="nofollow noopener" target="_blank">#EfectoSéquito</a> <a href="https://mastodon.cr/tags/entourageeffect" class="mention hashtag" rel="nofollow noopener" target="_blank">#entourageeffect</a> <a href="https://mastodon.cr/tags/thca" class="mention hashtag" rel="nofollow noopener" target="_blank">#thca</a> <a href="https://mastodon.cr/tags/cbn" class="mention hashtag" rel="nofollow noopener" target="_blank">#cbn</a> <a href="https://mastodon.cr/tags/alzheimers" class="mention hashtag" rel="nofollow noopener" target="_blank">#alzheimers</a> <a href="https://mastodon.cr/tags/neuroscience" class="mention hashtag" rel="nofollow noopener" target="_blank">#neuroscience</a>

JADe (he, him)<a href="https://mastodon.social/@SteveThompson" class="u-url mention" rel="nofollow noopener" target="_blank">@SteveThompson</a> Nice skeptic article as any true science should be. Anything that links the 2011 Russo paper "Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects" is to be celebrated. Here is the link again in case somebody missed it. <a href="https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01238.x" rel="nofollow noopener" translate="no" target="_blank">https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01238.x</a>Russo's paper has been cited 1,161 times and it deals with exogenous cannabinoids and terpenes synergy, not just endogenous o made inside our body, as did the original 1998 Mechoulam research.Indeed, due to obsolete prohibitionism and sad profit-comes-first mentality, the current cannabis and hemp markets are a wild west of fake adultered product and unproven claims. Yet since 2011 hundreds of studies have confirmed the entourage effect. Here is a small and incomplete collection of full spectrum extract papers 2004-2023.<a href="https://www.cvresearch.info/full-spectrum-hemp-extracts-studies" rel="nofollow noopener" translate="no" target="_blank">https://www.cvresearch.info/full-spectrum-hemp-extracts-studies</a>OPs article calls for more standarized extract testing, even though Big Pharmas really prefers patentable, cheap to make, single molecule, symptom masking drugs. Good luck with that.I agree with the article bottomline: governments should step up to the research task instead of trusting this critical matter to profit-driven corporations. Mixed isolate cannabis pharmaceuticals have been in the market for over a decade and proven their capabilities and limitations. That is the case of Sativex, a 700 US$ 1:1 (thc:cbd) oral spray that controls some symptoms of MS yet fails to work for other conditions. Three separate studies ( Israeli, Brazilian and American) have since proven that full flower artisanal extracts are up to 6x more effective than expensive isolate preparations like Sativex <a href="https://sensiseeds-com.translate.goog/es/blog/sativex-el-pionero-de-los-farmacos-derivados-del-cannabis/?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=es-419&_x_tr_pto=wapp" rel="nofollow noopener" translate="no" target="_blank">https://sensiseeds-com.translate.goog/es/blog/sativex-el-pionero-de-los-farmacos-derivados-del-cannabis/?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=es-419&_x_tr_pto=wapp</a><a href="https://mastodon.cr/tags/Cannabis" class="mention hashtag" rel="nofollow noopener" target="_blank">#Cannabis</a> <a href="https://mastodon.cr/tags/cannabismedicinal" class="mention hashtag" rel="nofollow noopener" target="_blank">#cannabismedicinal</a> <a href="https://mastodon.cr/tags/thc" class="mention hashtag" rel="nofollow noopener" target="_blank">#thc</a> <a href="https://mastodon.cr/tags/thca" class="mention hashtag" rel="nofollow noopener" target="_blank">#thca</a> <a href="https://mastodon.cr/tags/cbd" class="mention hashtag" rel="nofollow noopener" target="_blank">#cbd</a> <a href="https://mastodon.cr/tags/cbda" class="mention hashtag" rel="nofollow noopener" target="_blank">#cbda</a> <a href="https://mastodon.cr/tags/entourageeffect" class="mention hashtag" rel="nofollow noopener" target="_blank">#entourageeffect</a> <a href="https://mastodon.cr/tags/cannabislegal" class="mention hashtag" rel="nofollow noopener" target="_blank">#cannabislegal</a> <a href="https://mastodon.cr/tags/Cannabisgesetz" class="mention hashtag" rel="nofollow noopener" target="_blank">#Cannabisgesetz</a> <a href="https://mastodon.cr/tags/cannabislegalisierung" class="mention hashtag" rel="nofollow noopener" target="_blank">#cannabislegalisierung</a> <a href="https://mastodon.cr/tags/ganja" class="mention hashtag" rel="nofollow noopener" target="_blank">#ganja</a> <a href="https://mastodon.cr/tags/maconha" class="mention hashtag" rel="nofollow noopener" target="_blank">#maconha</a> <a href="https://mastodon.cr/tags/weed" class="mention hashtag" rel="nofollow noopener" target="_blank">#weed</a> <a href="https://mastodon.cr/tags/cannabisculture" class="mention hashtag" rel="nofollow noopener" target="_blank">#cannabisculture</a> <a href="https://mastodon.cr/tags/cannabisresearch" class="mention hashtag" rel="nofollow noopener" target="_blank">#cannabisresearch</a> <a href="https://mastodon.cr/tags/chronicillness" class="mention hashtag" rel="nofollow noopener" target="_blank">#chronicillness</a> <a href="https://mastodon.cr/tags/ptsd" class="mention hashtag" rel="nofollow noopener" target="_blank">#ptsd</a> <a href="https://mastodon.cr/tags/arthritis" class="mention hashtag" rel="nofollow noopener" target="_blank">#arthritis</a> <a href="https://mastodon.cr/tags/stress" class="mention hashtag" rel="nofollow noopener" target="_blank">#stress</a> <a href="https://mastodon.cr/tags/depression" class="mention hashtag" rel="nofollow noopener" target="_blank">#depression</a> <a href="https://mastodon.cr/tags/multiplesclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#multiplesclerosis</a> <a href="https://mastodon.cr/tags/ImmuneSystem" class="mention hashtag" rel="nofollow noopener" target="_blank">#ImmuneSystem</a>

JADe (he, him)<a href="https://mstdn.party/@copter_chief" class="u-url mention" rel="nofollow noopener" target="_blank">@copter_chief</a> godspeed in your healing journey. Some words of advice:Latest anticancer protocol calls for VERY GRADUAL dosage increase until reaching 5X the patient's weight in daily MG of COMBINED cannabinoids (not just THC). A 60 Kg patient should aim to consume and maintain 300 MG of daily cannabinoids. It should be in 3 daily doses of 100 MG in each meal to generate sufficient metabolic pressure. Start with 10-20 MG each night and gradually increase the dose/add the other doses over a couple of weeks to acclimate the body.Prefer FECO (Full Extract Cannabis Oil) whose solvent has been slowly evaporated below 55°C or ROSIN oil (then partly decarbed in double boiler for 25 minutes at 90°C). Both contain up to 60% cannabinoids as well as some of the flower's original terpenes, which are lost in other forms of extraction. Not only are they more effective as anticancer agents, but their psychotropic effect is less severe.I recommend a 1:1 balanced flower or a blend of two strains, one CBDA/CBD rich and other THCA/THC rich. If heated excessively or for too long, as per the original RSO recipe from 20 years, the acidic forms of THCA and CBDA are lost. Latest research has proven their anticancer, antiemetic, anxiolytic, antiinflammatory, and even neuroprotective effect through pathways different from THC/CBN.RSO Rick Simpson Oil recipes overcook and leave nothing but THC and CBN (oxidized THC), requiring incapacitating megadoses of 2,000 MG/day. CBD-deficient "recreational" cannabis will lack modulation. Non <a href="https://mastodon.cr/tags/Stoner" class="mention hashtag" rel="nofollow noopener" target="_blank">#Stoner</a> patients risk anxiety attacks/paranoia. Start low, increase slowly and use the right stuff.Vaping doesn't generate enough metabolic pressure for anticancer effect. It will reduce nausea and pain quickly, but it's palliative. Smoking destroys half the medicine and generates nasty toxins.<a href="https://mastodon.cr/tags/cannabismedicinal" class="mention hashtag" rel="nofollow noopener" target="_blank">#cannabismedicinal</a> <a href="https://mastodon.cr/tags/cancer" class="mention hashtag" rel="nofollow noopener" target="_blank">#cancer</a> <a href="https://mastodon.cr/tags/Cannabis" class="mention hashtag" rel="nofollow noopener" target="_blank">#Cannabis</a> <a href="https://mastodon.cr/tags/marijuana" class="mention hashtag" rel="nofollow noopener" target="_blank">#marijuana</a> <a href="https://mastodon.cr/tags/thc" class="mention hashtag" rel="nofollow noopener" target="_blank">#thc</a> <a href="https://mastodon.cr/tags/cbd" class="mention hashtag" rel="nofollow noopener" target="_blank">#cbd</a> <a href="https://mastodon.cr/tags/thca" class="mention hashtag" rel="nofollow noopener" target="_blank">#thca</a> <a href="https://mastodon.cr/tags/cbda" class="mention hashtag" rel="nofollow noopener" target="_blank">#cbda</a> <a href="https://mastodon.cr/tags/weed" class="mention hashtag" rel="nofollow noopener" target="_blank">#weed</a> <a href="https://mastodon.cr/tags/entourageeffect" class="mention hashtag" rel="nofollow noopener" target="_blank">#entourageeffect</a> <a href="https://mastodon.cr/tags/marihuana" class="mention hashtag" rel="nofollow noopener" target="_blank">#marihuana</a> <a href="https://mastodon.cr/tags/ganja" class="mention hashtag" rel="nofollow noopener" target="_blank">#ganja</a> <a href="https://mastodon.cr/tags/Cannabisgesetz" class="mention hashtag" rel="nofollow noopener" target="_blank">#Cannabisgesetz</a> <a href="https://mastodon.cr/tags/maconha" class="mention hashtag" rel="nofollow noopener" target="_blank">#maconha</a> <a href="https://mastodon.cr/tags/corporategreed" class="mention hashtag" rel="nofollow noopener" target="_blank">#corporategreed</a> <a href="https://mastodon.cr/tags/solarpunk" class="mention hashtag" rel="nofollow noopener" target="_blank">#solarpunk</a> <a href="https://mastodon.cr/tags/solarpunksunday" class="mention hashtag" rel="nofollow noopener" target="_blank">#solarpunksunday</a> <a href="https://mastodon.cr/tags/righttorepair" class="mention hashtag" rel="nofollow noopener" target="_blank">#righttorepair</a>

JADe (he, him)CBD isolate works best for antipsychotic and anxiolitic therapies. All other conditions, including pain, spasm, nausea, diabetes, autoimmune conditions, even epilepsy and mood disorders require a little or quite a bit of THC or CBN ( oxidized THC).Lets talk about dosage (less is more), delivery methods (to smoke or not), how to properly mix cannabinoids & terpenes for entourage effect in specific conditions ( <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7324885/" rel="nofollow noopener" translate="no" target="_blank">https://pmc.ncbi.nlm.nih.gov/articles/PMC7324885/</a> ), dependency, proven risks, pharmacological interactions... Got questions ? Open 🧶 now !<a href="https://mastodon.cr/tags/cannabis" class="mention hashtag" rel="nofollow noopener" target="_blank">#cannabis</a> <a href="https://mastodon.cr/tags/Cannabisgesetz" class="mention hashtag" rel="nofollow noopener" target="_blank">#Cannabisgesetz</a> <a href="https://mastodon.cr/tags/cannabislegalisierung" class="mention hashtag" rel="nofollow noopener" target="_blank">#cannabislegalisierung</a> <a href="https://mastodon.cr/tags/cannabismedicinal" class="mention hashtag" rel="nofollow noopener" target="_blank">#cannabismedicinal</a> <a href="https://mastodon.cr/tags/thc" class="mention hashtag" rel="nofollow noopener" target="_blank">#thc</a> <a href="https://mastodon.cr/tags/cbd" class="mention hashtag" rel="nofollow noopener" target="_blank">#cbd</a> <a href="https://mastodon.cr/tags/cbn" class="mention hashtag" rel="nofollow noopener" target="_blank">#cbn</a> <a href="https://mastodon.cr/tags/thca" class="mention hashtag" rel="nofollow noopener" target="_blank">#thca</a> <a href="https://mastodon.cr/tags/terpenoids" class="mention hashtag" rel="nofollow noopener" target="_blank">#terpenoids</a> <a href="https://mastodon.cr/tags/entourageeffect" class="mention hashtag" rel="nofollow noopener" target="_blank">#entourageeffect</a> <a href="https://mastodon.cr/tags/medicinalplants" class="mention hashtag" rel="nofollow noopener" target="_blank">#medicinalplants</a> <a href="https://mastodon.cr/tags/solarpunk" class="mention hashtag" rel="nofollow noopener" target="_blank">#solarpunk</a> <a href="https://mastodon.cr/tags/regenerativemedicine" class="mention hashtag" rel="nofollow noopener" target="_blank">#regenerativemedicine</a> <a href="https://mastodon.cr/tags/cannabismedicine" class="mention hashtag" rel="nofollow noopener" target="_blank">#cannabismedicine</a> <a href="https://mastodon.cr/tags/maconha" class="mention hashtag" rel="nofollow noopener" target="_blank">#maconha</a> <a href="https://mastodon.cr/tags/Endocannabinoide" class="mention hashtag" rel="nofollow noopener" target="_blank">#Endocannabinoide</a> <a href="https://mastodon.cr/tags/weed" class="mention hashtag" rel="nofollow noopener" target="_blank">#weed</a> <a href="https://mastodon.cr/tags/pot" class="mention hashtag" rel="nofollow noopener" target="_blank">#pot</a>

JADe (he, him)A farewell to Pepe Mujica, who recently passed away and really led by example ( ESPAÑOL MÁS ABAJO)ENG: "He established an agenda of rights that marked his administration by fire; he promoted the 8-hour working day for rural workers when he was Minister of Livestock, and during his term of office, the day of the rural worker was declared, which is celebrated every 30 April; The law on the voluntary interruption of pregnancy (with the main rationale of accompanying women in their decision and not as a mere act of ending a life); the regulation of marijuana consumption, which put Uruguay in the international spotlight as a testing ground for the legalisation of all drugs in order to put an end to a war that only leaves deaths along the way."ESP: "Consagró una agenda de derechos que marcaron a fuego su gestión; promovió las 8 horas para el trabajador rural siendo ministro de Ganadería, y durante su mandato se declaró el día del peón rural que se celebra cada 30 de abril; el matrimonio igualitario, la ley de interrupción voluntaria del embarazo (con la fundamentación principal de acompañar a las mujeres en la decisión y no como un mero acto de poner fin a una vida); la regulación del consumo de marihuana, con la que puso al Uruguay en la mira internacional como un campo de prueba hacia la legalización de todas las drogas para poner fin a una guerra que solo deja muertos por el camino."<a href="https://otromundoinfo.wordpress.com/2025/05/14/naides-es-mas-que-naides/" rel="nofollow noopener" translate="no" target="_blank">https://otromundoinfo.wordpress.com/2025/05/14/naides-es-mas-que-naides/</a><a href="https://mastodon.cr/tags/pepemujica" class="mention hashtag" rel="nofollow noopener" target="_blank">#pepemujica</a> <a href="https://mastodon.cr/tags/pepe_mujica" class="mention hashtag" rel="nofollow noopener" target="_blank">#pepe_mujica</a> <a href="https://mastodon.cr/tags/cannabis" class="mention hashtag" rel="nofollow noopener" target="_blank">#cannabis</a> <a href="https://mastodon.cr/tags/cannabismedicinal" class="mention hashtag" rel="nofollow noopener" target="_blank">#cannabismedicinal</a> <a href="https://mastodon.cr/tags/cannabislegalisierung" class="mention hashtag" rel="nofollow noopener" target="_blank">#cannabislegalisierung</a> <a href="https://mastodon.cr/tags/legaliza" class="mention hashtag" rel="nofollow noopener" target="_blank">#legaliza</a> <a href="https://mastodon.cr/tags/legalization" class="mention hashtag" rel="nofollow noopener" target="_blank">#legalization</a> <a href="https://mastodon.cr/tags/cannabinoide" class="mention hashtag" rel="nofollow noopener" target="_blank">#cannabinoide</a> <a href="https://mastodon.cr/tags/thc" class="mention hashtag" rel="nofollow noopener" target="_blank">#thc</a> <a href="https://mastodon.cr/tags/cbd" class="mention hashtag" rel="nofollow noopener" target="_blank">#cbd</a> <a href="https://mastodon.cr/tags/cbn" class="mention hashtag" rel="nofollow noopener" target="_blank">#cbn</a> <a href="https://mastodon.cr/tags/thca" class="mention hashtag" rel="nofollow noopener" target="_blank">#thca</a> <a href="https://mastodon.cr/tags/maconha" class="mention hashtag" rel="nofollow noopener" target="_blank">#maconha</a> <a href="https://mastodon.cr/tags/marijuana" class="mention hashtag" rel="nofollow noopener" target="_blank">#marijuana</a> <a href="https://mastodon.cr/tags/marihuana" class="mention hashtag" rel="nofollow noopener" target="_blank">#marihuana</a> <a href="https://mastodon.cr/tags/PatientCare" class="mention hashtag" rel="nofollow noopener" target="_blank">#PatientCare</a> <a href="https://mastodon.cr/tags/Cannabinoids" class="mention hashtag" rel="nofollow noopener" target="_blank">#Cannabinoids</a> <a href="https://mastodon.cr/tags/Endocannabinoide" class="mention hashtag" rel="nofollow noopener" target="_blank">#Endocannabinoide</a> <a href="https://mastodon.cr/tags/EfectoS%C3%A9quito" class="mention hashtag" rel="nofollow noopener" target="_blank">#EfectoSéquito</a> <a href="https://mastodon.cr/tags/entourageeffect" class="mention hashtag" rel="nofollow noopener" target="_blank">#entourageeffect</a>

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