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#polymorphism

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Cytology and Genetics

Association of the rs4646994 Polymorphism in the ACE1 Gene with the Severity of COVID-19 in Children from Ukraine - #children #COVID19 #lunginjury #geneticmarker #IDpolymorphismoftheACE1gene #Ukraine #rs4646994 #polymorphism #ACE1gene - link.springer.com/article/10.3

SpringerLinkAssociation of the rs4646994 Polymorphism in the ACE1 Gene with the Severity of COVID-19 in Children from Ukraine - Cytology and GeneticsAbstract Coronavirus disease 2019 (COVID-19), first identified in late 2019 in Wuhan City, Hubei Province, China, remains a pressing public health challenge of the twenty-first century with significant morbidity and mortality despite the implementation of a vaccine campaign. Of particular interest are results of research on the role of genetic factors in the course of COVID-19. Such data indicate the probable existence of a hereditary predisposition of individuals to a severe and complicated course of the coronavirus disease. The results of a number of studies indicate the involvement of polymorphic variants I/D of the ACE1 gene in the particular course of the corona virus disease. The purposes of this work were to study the peculiarities of the distribution of genotypes according to the rs4646994 polymorphism of the ACE1 gene and to assess the association of this polymorphism with the severity of the course of the coronavirus disease and the risk of developing pathological changes in the lungs during the coronavirus disease in a cohort of children who suffered from COVID-19. For this purpose, in the examined group of 244 children with laboratory-confirmed COVID-19, genotyping was carried out according to the rs4646994 polymorphism of the ACE1 gene using melting curve analysis of PCR products, the detection of which occurs due to the fluorescence of the intercalating dye EvaGreen. According to the results of the study, an association was established between homo- and heterozygous carriers of the I allele with a severe course of the disease and, in particular, with lung injury. The obtained data can serve as a basis for the use of the I/D polymorphism of the ACE1 gene as a genetic marker for predicting the course of the disease for COVID-19 and become important information for the development of personalized therapy in children.
Planetary Ecologist

Genotype (Genetics 🧬)

The genotype of an organism is its complete set of genetic material. Genotype can also be used to refer to the alleles or variants an individual carries in a particular gene or genetic location. The number of alleles an individual can have in a specific gene depends on the number of copies of each chromosome found in that species, also referred to as ploidy. In diploid species like...

en.wikipedia.org/wiki/Genotype

#Genotype#Genetics#DnaSequencing
Giuseppe Michieli

An emerging #PB2-627 #polymorphism increases #pandemic #potential of avian #influenza virus by breaking through ANP32 host restriction in #mammalian & avian hosts, BioRxIV: biorxiv.org/content/10.1101/20

by screening the global PB2 seq., we discovered a new independent cluster with PB2-627V emerged in the '10s, which is prevalent in various avian, mammalian, & human isolates of AIVs, including #H9N2, #H7N9, #H3N8, 2.3.4.4b #H5N1, and other subtypes.

Giuseppe Michieli

An emerging #PB2-627 #polymorphism increases the #pandemic #potential of avian #influenza virus by breaking through ANP32 #host #restriction in #mammalian and avian hosts, BioRxIV: biorxiv.org/content/10.1101/20

...we discovered a new independent #cluster with PB2-627V emerged in the 2010s, which is prevalent in various avian, mammalian, and human isolates of AIVs, including #H9N2, #H7N9, #H3N8, 2.3.4.4b #H5N1, and other subtypes.

bioRxiv · An emerging PB2-627 polymorphism increases the pandemic potential of avian influenza virus by breaking through ANP32 host restriction in mammalian and avian hostsAlterations in the PB2-627 domain could substantially increase the risk of an avian influenza virus (AIV) pandemic. So far, a well-known mammalian mutation PB2-E627K has not been maintained in AIV in poultry, which limits the spread of AIVs from avian to humans. Here, we discovered a variant, PB2-627V, which combines the properties of avian-like PB2-627E and human-like PB2-627K, overcoming host restrictions and posing a risk for human pandemics. Specifically, by screening the global PB2 sequences, we discovered a new independent cluster with PB2-627V emerged in the 2010s, which is prevalent in various avian, mammalian, and human isolates of AIVs, including H9N2, H7N9, H3N8, 2.3.4.4b H5N1, and other subtypes. And, the increasing prevalence of PB2-627V in poultry is accompanied by a rise in human infection cases with this variant. Then we systematically assessed its host adaptation, fitness, and transmissibility across three subtypes of AIVs (H9N2, H7N9, and H3N8) in different host models, including avian and human cells, chickens, mice, and ferrets where infections naturally occur. We found that PB2-627V facilitates AIVs to efficiently replicate and infect chickens and mice by utilizing both avian- and human-origin ANP32A proteins. Importantly, and like PB2-627K, PB2-627V promotes efficient transmission between ferrets through respiratory droplets. Deep sequencing in passaged chicken samples and transmitted ferret samples indicates PB2-627V maintains stable functionality across the two distinct hosts. Therefore, the mutation has the ability to continue spreading among poultry and can also overcome the barrier between birds and humans, greatly enhancing the likelihood of AIVs infecting humans. Given the escalating global spread of AIVs, it is crucial to closely monitor influenza viruses carrying PB2-627V to prevent a pandemic. ### Competing Interest Statement The authors have declared no competing interest.
Giuseppe Michieli

An emerging #PB2-627 #polymorphism increases the #pandemic #potential of avian #influenza virus by breaking through ANP32 #host restriction in #mammalian and avian #hosts, BioRxIV, biorxiv.org/content/10.1101/20

The PB2-627V polymorphism has been found in birds, humans, and mammals worldwide across more than ten AIV #subtypes. Given the escalating global spread of AIVs, it is crucial to closely monitor influenza viruses carrying PB2-627V to prevent a pandemic.

bioRxiv · An emerging PB2-627 polymorphism increases the pandemic potential of avian influenza virus by breaking through ANP32 host restriction in mammalian and avian hostsAlterations in the PB2-627 domain could substantially increase the risk of an avian influenza virus (AIV) pandemic. Here, we discovered a variant, PB2-627V, which combines the properties of avian-like PB2-627E and human-like PB2-627K. This variant not only maintains viral fitness in chickens but also facilitates the aerosol transmission of AIVs between ferrets. Mechanistically, PB2-627V utilizes both avian and human host protein ANP32A to support viral polymerase function. Therefore, this mutation overcomes the barrier between birds and humans, greatly enhancing the likelihood of AIVs infecting humans. The PB2-627V polymorphism has been found in birds, humans, and mammals worldwide across more than ten AIV subtypes. Given the escalating global spread of AIVs, it is crucial to closely monitor influenza viruses carrying PB2-627V to prevent a pandemic. ### Competing Interest Statement The authors have declared no competing interest.
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Stefan F. Wirth

About the #diphenism in #migratorylocusts with an #explication about the #difference between #polymorphism and #polyphenism, and about new research on the function of #olfactory #perception in a #swarm related to the context of perceiving #conspecifics and #food

© #StefanFWirth 2024

My #blog article on "#biologe"
wp.me/p2l6XU-1Tp

Source
I. Petelski et al. preprint (2023):
doi.org/10.1101/2023.09.15.557

#photos #Schistocerca #gregaria, fig1 is a freshly #molted #adult ©S. F. Wirth

billseipel

We have a database "rules engine" that I greatly dislike. The maintenance of it is especially troubling.

It is essentially a huge Conditional statement. Which leads me to Martin Fowler's solution: conditionals as polymorphism.

Which led me to use JSON schemas to define the polymorphed classes at runtime. But #polymorphism in #json isnt quite that simple.

I've also considered the #specification pattern. But maintaining specifications is the issue.

Still thinking.

#designpatterns#dotnet
Darren Obbard

Day8: Lordiphosa andalusiaca—Our first #Advent species not in #Drosophila: a distinctive #Fly with a striking colour #polymorphism (brill.com/view/journals/anz/17 - ours is a dark one). Lordiphosa like rotting plants drosophila.jp/jdd/class/030704 and some species have sex combs doi.org/10.1111/evo.14564 . It gives us two lessons in systematics: [1] #Drosophilid #Taxonomy doesn’t match #Phylogeny academic.oup.com/gbe/article/1 ; [2] Do not let people play word games with your (sub)genera... cf. Phloridosa & Siphlodora

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Jay 钻升 Falk

ok #introduction I'm an #evolutionarybiologist and #behavioralecologist studying how social interactions lead to biodiversity. I'm big on #socialselection, #polymorphism, #color, #genetics and #teaching /course development (queer bio woo!).

My main study organisms are #hummingbirds, especially white-necked jacobins (Florisuga mellivora), which have female polymorphism -- 20% females look like males, while the rest look different. I love them 💓

🎨 📸 :Jillian Ditner & Irene Mendez Cruz

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