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#subvariants

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Giuseppe Michieli<p><a href="https://mstdn.science/tags/Neutralization" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neutralization</span></a> and <a href="https://mstdn.science/tags/Stability" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Stability</span></a> of <a href="https://mstdn.science/tags/JN1" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>JN1</span></a>-derived <a href="https://mstdn.science/tags/LB1" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>LB1</span></a>, <a href="https://mstdn.science/tags/KP23" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>KP23</span></a>, <a href="https://mstdn.science/tags/KP3" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>KP3</span></a> and <a href="https://mstdn.science/tags/KP311" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>KP311</span></a> <a href="https://mstdn.science/tags/Subvariants" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Subvariants</span></a> <a href="http://biorxiv.org/cgi/content/short/2024.09.04.611219v1?rss=1" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">http://</span><span class="ellipsis">biorxiv.org/cgi/content/short/</span><span class="invisible">2024.09.04.611219v1?rss=1</span></a> </p><p>We report on the neutralizing <a href="https://mstdn.science/tags/antibody" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>antibody</span></a> (nAb) <a href="https://mstdn.science/tags/escape" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>escape</span></a>, infectivity, <a href="https://mstdn.science/tags/fusion" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>fusion</span></a>, and stability of these subvariants-LB.1, KP.2.3, KP.3, and KP.3.1.1. Our findings demonstrate that all of these subvariants are highly evasive of nAbs elicited by bivalent <a href="https://mstdn.science/tags/mRNA" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>mRNA</span></a> <a href="https://mstdn.science/tags/vaccine" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>vaccine</span></a>, the <a href="https://mstdn.science/tags/XBB15" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>XBB15</span></a> monovalent mumps virus-based vaccine, or from infections during the BA.2.86/JN.1 wave.</p>
Giuseppe Michieli<p>Structural <a href="https://mstdn.science/tags/basis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>basis</span></a> for the <a href="https://mstdn.science/tags/evolution" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>evolution</span></a> and <a href="https://mstdn.science/tags/antibody" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>antibody</span></a> <a href="https://mstdn.science/tags/evasion" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>evasion</span></a> of <a href="https://mstdn.science/tags/SARS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SARS</span></a>-CoV-2 <a href="https://mstdn.science/tags/BA286" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>BA286</span></a> and <a href="https://mstdn.science/tags/JN1" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>JN1</span></a> <a href="https://mstdn.science/tags/subvariants" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>subvariants</span></a> <a href="https://www.nature.com/articles/s41467-024-51973-8" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nature.com/articles/s41467-024</span><span class="invisible">-51973-8</span></a> </p><p>Here, the authors evaluate the neutralization susceptibilities of BA.2.86 and JN.1 and determine the structural basis for binding to the ACE2 receptor and monoclonal neutralizing antibodies, revealing their evolution and antibody evasion mechanism.</p>
The Kyiv Independent [unofficial]<p>Ukraine Daily Summary - Tuesday, August 6 2024</p><p>SBU intercepts large-scale FSB saboteur network across Ukraine -- Russian Su-34 jet destroyed in Ukraine's strike on Morozovsk airfield -- The path to peace in Europe -- EU should reconsider Hungary's Schengen membership over easing visa rules for Russia, MEPs say -- and more</p><p><a href="https://writeworks.uk/~/UkraineDaily/Ukraine%20Daily%20Summary%20-%20Tuesday,%20August%206%202024/" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">writeworks.uk/~/UkraineDaily/U</span><span class="invisible">kraine%20Daily%20Summary%20-%20Tuesday,%20August%206%202024/</span></a></p>
Giuseppe Michieli<p><a href="https://mstdn.science/tags/Virological" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Virological</span></a> characteristics of the <a href="https://mstdn.science/tags/SarsCoV2" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SarsCoV2</span></a> <a href="https://mstdn.science/tags/KP3" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>KP3</span></a>, <a href="https://mstdn.science/tags/LB1" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>LB1</span></a> and <a href="https://mstdn.science/tags/KP23" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>KP23</span></a> <a href="https://mstdn.science/tags/variants" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>variants</span></a>, BioRxIV, <a href="https://www.biorxiv.org/content/10.1101/2024.06.05.597664v1?rss=1" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">biorxiv.org/content/10.1101/20</span><span class="invisible">24.06.05.597664v1?rss=1</span></a> </p><p>Our results suggest that S <a href="https://mstdn.science/tags/substitutions" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>substitutions</span></a> convergently acquired in <a href="https://mstdn.science/tags/JN1" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>JN1</span></a> <a href="https://mstdn.science/tags/subvariants" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>subvariants</span></a> contribute to immune evasion, &amp; increase their Re when compared to parental JN.1. LB.1 &amp; KP.2.3 exhibited higher pseudovirus <a href="https://mstdn.science/tags/infectivity" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>infectivity</span></a> &amp; more immune resistance than KP.2. Data suggest that S:S31del is critical to exhibit +infectivity, +immune evasion, &amp; potentially contributes to increased Re.</p>
Giuseppe Michieli<p><a href="https://mstdn.science/tags/Durability" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Durability</span></a> of <a href="https://mstdn.science/tags/XBB15" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>XBB15</span></a> <a href="https://mstdn.science/tags/Vaccines" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Vaccines</span></a> against <a href="https://mstdn.science/tags/Omicron" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Omicron</span></a> <a href="https://mstdn.science/tags/Subvariants" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Subvariants</span></a>, N Engl J Med.: <a href="https://www.nejm.org/doi/full/10.1056/NEJMc2402779?query=TOC&amp;cid=DM2342986_Non_Subscriber&amp;bid=-1971795569" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nejm.org/doi/full/10.1056/NEJM</span><span class="invisible">c2402779?query=TOC&amp;cid=DM2342986_Non_Subscriber&amp;bid=-1971795569</span></a> </p><p>Overall, the XBB.1.5 vaccines were effective against omicron subvariants, although less so against <a href="https://mstdn.science/tags/JN1" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>JN1</span></a>. Effectiveness was greater against <a href="https://mstdn.science/tags/hospitalization" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>hospitalization</span></a> and <a href="https://mstdn.science/tags/death" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>death</span></a> than against infection, and it waned moderately from its peak over time. The ramping and waning patterns were broadly similar to those of the bivalent boosters against BQ.1–BQ.1.1 and XBB–XBB.1.5.3</p>
Giuseppe Michieli<p>Characteristics of <a href="https://mstdn.science/tags/JN1" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>JN1</span></a>-derived <a href="https://mstdn.science/tags/SarsCoV2" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SarsCoV2</span></a> <a href="https://mstdn.science/tags/subvariants" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>subvariants</span></a> <a href="https://mstdn.science/tags/SLip" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SLip</span></a>, <a href="https://mstdn.science/tags/FLiRT" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>FLiRT</span></a>, and <a href="https://mstdn.science/tags/KP2" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>KP2</span></a> in neutralization <a href="https://mstdn.science/tags/escape" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>escape</span></a>, <a href="https://mstdn.science/tags/infectivity" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>infectivity</span></a> and membrane <a href="https://mstdn.science/tags/fusion" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>fusion</span></a> <a href="http://biorxiv.org/cgi/content/short/2024.05.20.595020v1?rss=1" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">http://</span><span class="ellipsis">biorxiv.org/cgi/content/short/</span><span class="invisible">2024.05.20.595020v1?rss=1</span></a> </p><p>Interestingly, <a href="https://mstdn.science/tags/antibodies" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>antibodies</span></a> in <a href="https://mstdn.science/tags/XBB15" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>XBB15</span></a> monovalent vaccinated hamster sera robustly neutralized FLiRT and KP.2 but had reduced efficiency for SLip.</p>
Giuseppe Michieli<p>[Correspondence] Antiviral humoral <a href="https://mstdn.science/tags/immunity" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>immunity</span></a> against <a href="https://mstdn.science/tags/SARS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SARS</span></a>-CoV-2 <a href="https://mstdn.science/tags/omicron" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>omicron</span></a> <a href="https://mstdn.science/tags/subvariants" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>subvariants</span></a> induced by <a href="https://mstdn.science/tags/XBB15" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>XBB15</span></a> monovalent <a href="https://mstdn.science/tags/vaccine" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>vaccine</span></a> in <a href="https://mstdn.science/tags/infection" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>infection</span></a>-naive and XBB-infected individuals <a href="https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00784-3/fulltext?rss=yes" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">thelancet.com/journals/laninf/</span><span class="invisible">article/PIIS1473-3099(23)00784-3/fulltext?rss=yes</span></a></p>

People aren’t taking this seriously’: experts say US Covid surge is big risk

In the fourth #year of the pandemic, #Covid-19 is once again spreading across #America and being driven by the recent holidays, fewer precautions and the continuing evolution of Omicron #subvariants of the virus.
New sub-variants are causing concern for their #increased #transmissibility.

theguardian.com/world/2023/jan

#China, #Shanghai has detected the #Omicron #subvariants #BQ1 and #XBB that have been prevailing in some overseas countries but experts said 2 strains were found in imported cases placed under closed-loop management which has not caused local #transmission, saying there is no need to hoard Montmorillonite {?} powder to relieve #diarrhea that can be caused by subvariant #XBB15. GT: globaltimes.cn/page/202301/128

www.globaltimes.cnShanghai detects Omicron subvariants BQ.1 and XBB from imported cases - Global Times