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#facs

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DaveKaz

The new #FACS album is out today. A little less minimal and more wobbly than angular gives a new feel to the band. Also a bit less laid back. The monotone, drone like vocals remain. Overall a bit unsettling and other worldly. Excellent! Also the last album #SteveAlbini recorded before his death, may explain the more muscular sound. Neo-#PostPunk #Experimental #NowPlaying

wearefacs.bandcamp.com/album/w

FACSWish Defense, by FACS7 track album
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Gene From The Moon

FACS - Wish Defense (2025)

The sixth album by Chicago trio FACS is a deep dive into the human nature & duality. The return of original member Jonathan Van Herik brings a fresh dynamic, while Brian Case's lyrics explore who we truly are. The album was recorded by the legendary Steve Albini.

wearefacs.bandcamp.com/album/w

music.youtube.com/playlist?lis

The duality of “man” is a subject that has been explored in art for centuries, from writings of the Bible to Descartes, all the way up to filmmakers like Lynch, Cronenberg, & Carpenter. Who is your “true self” & what do they want? With their sixth studio album “Wish Defense” (again for longtime home Trouble In Mind Records), Chicago trio FACS take a good, long look in the mirror to face themselves. The return of original member Jonathan Van Herik - who stepped away from the group just before their debut album “Negative Houses” was released in 2018 - replacing longtime bassist Alianna Kalaba brings renewed vigor & a marked angularity from the band’s more recent output. The songs still hit hard, but the approach is sideways - the roles have changed since Van Herik’s original tenure & his previous time with Case & powerhouse drummer Noah Leger in Disappears; now on bass, Van Herik was originally the group’s guitar player and features on the debut, while current guitarist Brian Case played bass. “Wish Defense” is the last album engineered by Steve Albini. Two days were recorded at Electrical Audio in early May of 2024 before Steve’s untimely passing, with renowned engineer & friend Sanford Parker stepping in to finish the session 24 hours later, tracking the last bits of vocals and overdubs. Longtime collaborator John Congleton mixed the album as Albini would have; in Electrical Audio’s A room, off the tape, using Albini’s notes about the session. releases February 7, 2025
#music#facs#artrock
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Thiago Carvalho

Tools (#preprint)

"Our platform is built around a commercial instrument and integrates the handling and transfer of samples to and from the instrument, autonomous control of the instrument's software, and the algorithmic generation of sorting gates, resulting in walkaway functionality."

#FACS #FlowCytometry

biorxiv.org/content/10.1101/20

bioRxivAn open-source FACS automation system for high-throughput cell biologyRecent advances in gene editing are enabling the engineering of cells with an unprecedented level of scale. To capitalize on this opportunity, new methods are needed to accelerate the different steps required to manufacture and handle engineered cells. Here, we describe the development of an integrated software and hardware platform to automate Fluorescence-Activated Cell Sorting (FACS), a central step for the selection of cells displaying desired molecular attributes. Sorting large numbers of samples is laborious, and, to date, no automated system exists to sequentially manage FACS samples, likely owing to the need to tailor sorting conditions ("gating") to each individual sample. Our platform is built around a commercial instrument and integrates the handling and transfer of samples to and from the instrument, autonomous control of the instrument's software, and the algorithmic generation of sorting gates, resulting in walkaway functionality. Automation eliminates operator errors, standardizes gating conditions by eliminating operator-to-operator variations, and reduces hands-on labor by 93%. Moreover, our strategy for automating the operation of a commercial instrument control software in the absence of an Application Program Interface (API) exemplifies a universal solution for other instruments that lack an API. Our software and hardware designs are fully open-source and include step-by-step build documentation to contribute to a growing open ecosystem of tools for high-throughput cell biology. ### Competing Interest Statement The authors have declared no competing interest.
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