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#nejm

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Kelvin n0mql EN35ld<p><span class="h-card" translate="no"><a href="https://ctrvx.net/chema" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>chema</span></a></span> <br>Oh, MAN, I miss the early Internet days.</p><p>In 1991 or '92, I brought a tractor-fed dot-matrix printout about 8-10 pages long of a <a href="https://mastodon.hams.social/tags/NewEnglandJournalOfMedicine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NewEnglandJournalOfMedicine</span></a> <a href="https://mastodon.hams.social/tags/NEJM" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NEJM</span></a> article/study that was possibly related to my malady, to my <a href="https://mastodon.hams.social/tags/Cardiologist" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Cardiologist</span></a>, &amp; he was genuinely appreciative.</p><p>I'd used <a href="https://mastodon.hams.social/tags/gopher" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>gopher</span></a> to find it. Or was it <a href="https://mastodon.hams.social/tags/archie" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>archie</span></a> ?</p><p>Can you imagine a Dr these days paying ANY attention to something I printed off the Internet today?</p>
Nonilex<p><a href="https://masto.ai/tags/RFKJr" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>RFKJr</span></a>, <a href="https://masto.ai/tags/Trump" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Trump</span></a>’s *<a href="https://masto.ai/tags/health" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>health</span></a>* secy, singled out <a href="https://masto.ai/tags/NEJM" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NEJM</span></a> in an interview w/the “Dr. Hyman Show” podcast last year as an example of a <a href="https://masto.ai/tags/medical" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>medical</span></a> journal that has participated in “lying to the public” &amp; “retracting the real science.”</p><p>Andrew Nixon, a spox for the <a href="https://masto.ai/tags/HHS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>HHS</span></a>, declined to comment on whether RFKJr had any involvement w/the letters.</p><p>In the interview, RFKJr said he would seek to prosecute medical journals under federal anti-corruption laws.</p><p><a href="https://masto.ai/tags/law" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>law</span></a> <a href="https://masto.ai/tags/FirstAmendment" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>FirstAmendment</span></a> <a href="https://masto.ai/tags/Constitution" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Constitution</span></a> <a href="https://masto.ai/tags/dictatorship" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>dictatorship</span></a> <a href="https://masto.ai/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>science</span></a></p>
Nonilex<p>Amanda Shanor, a <a href="https://masto.ai/tags/FirstAmendment" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>FirstAmendment</span></a> expert at the University of Pennsylvania, said the information published in reputable <a href="https://masto.ai/tags/medical" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>medical</span></a> journals like <a href="https://masto.ai/tags/NEJM" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NEJM</span></a> is broadly protected by the <a href="https://masto.ai/tags/Constitution" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Constitution</span></a>.</p><p>In most cases, journals have the same robust rights that apply to newspapers — the strongest the Constitution provides, she added.</p><p><a href="https://masto.ai/tags/law" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>law</span></a> <a href="https://masto.ai/tags/censorship" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>censorship</span></a> <a href="https://masto.ai/tags/democracy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>democracy</span></a> <a href="https://masto.ai/tags/Trump" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Trump</span></a> <a href="https://masto.ai/tags/AbuseOfPower" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>AbuseOfPower</span></a> <a href="https://masto.ai/tags/authoritarianism" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>authoritarianism</span></a> <a href="https://masto.ai/tags/tyranny" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>tyranny</span></a> <a href="https://masto.ai/tags/dictatorship" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>dictatorship</span></a> <a href="https://masto.ai/tags/AntiIntellectualism" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>AntiIntellectualism</span></a> <a href="https://masto.ai/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>science</span></a> <a href="https://masto.ai/tags/medicine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>medicine</span></a></p>
Nonilex<p>Do they accept submissions from scientists with “competing viewpoints”? What do they do if the authors whose work they published “may have misled their readers”? Are they transparent about influence from “supporters, funders, advertisers &amp; others”?</p><p>News of the letter to <a href="https://masto.ai/tags/NEJM" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NEJM</span></a> was reported earlier by STAT, a health news outlet.</p><p><a href="https://masto.ai/tags/EdMartin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>EdMartin</span></a> also asked about the role of the <a href="https://masto.ai/tags/NIH" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NIH</span></a>, which funds some of the <a href="https://masto.ai/tags/research" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>research</span></a> the journals publish, &amp; the agency’s role “in the development of submitted articles.”</p>
Nonilex<p>A federal prosecutor in Washington has contacted The New England Journal of Medicine, considered the world’s most prestigious <a href="https://masto.ai/tags/medical" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>medical</span></a> journal, w/questions that suggested without evidence that it was biased against certain views &amp; influenced by external pressures.</p><p>Dr. Eric Rubin, the editor in chief of <a href="https://masto.ai/tags/NEJM" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NEJM</span></a>, described the letter as “vaguely threatening” in an interview with NYT.</p><p><a href="https://masto.ai/tags/law" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>law</span></a> <a href="https://masto.ai/tags/censorship" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>censorship</span></a> <a href="https://masto.ai/tags/FirstAmendment" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>FirstAmendment</span></a> <a href="https://masto.ai/tags/Constitution" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Constitution</span></a> <a href="https://masto.ai/tags/Trump" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Trump</span></a> <a href="https://masto.ai/tags/AbuseOfPower" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>AbuseOfPower</span></a> <a href="https://masto.ai/tags/AmericanAutocracy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>AmericanAutocracy</span></a> <a href="https://masto.ai/tags/tyranny" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>tyranny</span></a> <a href="https://masto.ai/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>science</span></a> <a href="https://masto.ai/tags/medicine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>medicine</span></a></p>
Nonilex<p>Madness <a href="https://masto.ai/tags/AmericanAutocracy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>AmericanAutocracy</span></a></p><p>‘Vaguely Threatening’: <a href="https://masto.ai/tags/Trump" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Trump</span></a> Federal Prosecutor <a href="https://masto.ai/tags/EdMartin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>EdMartin</span></a> Queries Leading <a href="https://masto.ai/tags/Medical" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Medical</span></a> Journal</p><p>The New England Journal of Medicine [<a href="https://masto.ai/tags/NEJM" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NEJM</span></a>] received a letter suggesting that it was biased &amp; compromised by external pressure. Other journals have also received the letter.</p><p><a href="https://masto.ai/tags/law" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>law</span></a> <a href="https://masto.ai/tags/censorship" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>censorship</span></a> <a href="https://masto.ai/tags/FirstAmendment" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>FirstAmendment</span></a> <a href="https://masto.ai/tags/Constitution" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Constitution</span></a> <a href="https://masto.ai/tags/democracy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>democracy</span></a> <a href="https://masto.ai/tags/AbuseOfPower" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>AbuseOfPower</span></a> <a href="https://masto.ai/tags/authoritarianism" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>authoritarianism</span></a> <a href="https://masto.ai/tags/tyranny" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>tyranny</span></a> <a href="https://masto.ai/tags/dictatorship" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>dictatorship</span></a> <a href="https://masto.ai/tags/AntiIntellectualism" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>AntiIntellectualism</span></a> <a href="https://masto.ai/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>science</span></a> <a href="https://masto.ai/tags/medicine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>medicine</span></a> <br><a href="https://www.nytimes.com/2025/04/25/health/nejm-prosecutor-letter.html?smid=nytcore-ios-share&amp;referringSource=articleShare&amp;sgrp=p&amp;pvid=68CE025A-703F-4C94-87AA-8D0D7D06D23B" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nytimes.com/2025/04/25/health/</span><span class="invisible">nejm-prosecutor-letter.html?smid=nytcore-ios-share&amp;referringSource=articleShare&amp;sgrp=p&amp;pvid=68CE025A-703F-4C94-87AA-8D0D7D06D23B</span></a></p>
George Macgregor<p>The <a href="https://code4lib.social/tags/Trump" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Trump</span></a> administration of lunacy continues its quest to take the <a href="https://code4lib.social/tags/USA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>USA</span></a> back to the Dark Ages -- and again demonstrates zero understanding of <a href="https://code4lib.social/tags/scholarship" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>scholarship</span></a>. Y'know, concepts like 'evidence', 'peer review', 'empiricism' (!?!?).</p><p>I guess I'm just astonished that so many US citizens are taking this insidious trolling lying down. I know many aren't. But some are. C'mon compadres, where is the 'Tea Party spirit'?!</p><p><a href="https://www.nytimes.com/2025/04/25/health/nejm-prosecutor-letter.html" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nytimes.com/2025/04/25/health/</span><span class="invisible">nejm-prosecutor-letter.html</span></a> <a href="https://code4lib.social/tags/NEJM" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NEJM</span></a> <a href="https://code4lib.social/tags/research" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>research</span></a> <a href="https://code4lib.social/tags/universities" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>universities</span></a></p>
DrBob, Neurologist, 🧠Mechanic<p>Not Surprising: Endovascular treatment (EVT) is beneficial in persons with an acute ischemic stroke caused by a large-vessel occlusion, but its efficacy not evident for treatment of stroke caused by occlusion of medium or distal vessels.</p><p><a href="https://vmst.io/tags/stroke" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>stroke</span></a> <a href="https://vmst.io/tags/endovasculartreatment" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>endovasculartreatment</span></a> <a href="https://vmst.io/tags/nejm" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>nejm</span></a></p>
Giuseppe Michieli<p><a href="https://mstdn.science/tags/NEJM" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NEJM</span></a> <a href="https://mstdn.science/tags/Outbreaks" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Outbreaks</span></a> <a href="https://mstdn.science/tags/Update" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Update</span></a> — <a href="https://mstdn.science/tags/H5N1" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>H5N1</span></a>, <a href="https://www.nejm.org/doi/full/10.1056/NEJMe2502267?query=TOC&amp;cid=DM2392650_Non_Subscriber&amp;bid=-1425531110" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nejm.org/doi/full/10.1056/NEJM</span><span class="invisible">e2502267?query=TOC&amp;cid=DM2392650_Non_Subscriber&amp;bid=-1425531110</span></a> </p><p>In this NEJM Outbreaks Update, Editor-in-Chief Eric <a href="https://mstdn.science/tags/Rubin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Rubin</span></a> and Deputy Editor Lindsey Baden are joined by veterinarian and <a href="https://mstdn.science/tags/virologist" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>virologist</span></a> Yoshihiro <a href="https://mstdn.science/tags/Kawaoka" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Kawaoka</span></a> to discuss avian influenza and its current impact on chickens, cows, cats, and humans.</p>
Christos Argyropoulos MD, PhD<p>Gotta give thumbs up to <a href="https://med-mastodon.com/tags/NEJM" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NEJM</span></a> Pain Management modules</p>
Christos Argyropoulos MD PhD<p>Gotta give thumbs up to <a href="https://mastodon.social/tags/NEJM" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NEJM</span></a> Pain Management modules</p>
Maggie Maybe<p>Details about the kid in Canada hospitalized from bird flu.</p><p>Critical Illness in an Adolescent with Influenza A(H5N1) Virus Infection | New England Journal of Medicine <a href="https://www.nejm.org/doi/full/10.1056/NEJMc2415890" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nejm.org/doi/full/10.1056/NEJM</span><span class="invisible">c2415890</span></a> </p><p><a href="https://zeroes.ca/tags/H5N1" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>H5N1</span></a> <a href="https://zeroes.ca/tags/NEJM" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NEJM</span></a></p>
DrBob, Neurologist, 🧠Mechanic<p>Entering a New Era in <a href="https://vmst.io/tags/SleepApnea" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SleepApnea</span></a> Treatment</p><p>TL:DR Tirzepatide resulted in 50% reduction in AHI (apnea-hypoxia index) and a lowering of blood pressure (which may reduce risk of stroke and heart attack!)</p><p><a href="https://vmst.io/tags/ObstructiveSleepApnea" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ObstructiveSleepApnea</span></a> is one of the most common respiratory disorders worldwide. Persons with obstructive sleep apnea can have loud <a href="https://vmst.io/tags/Snoring" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Snoring</span></a> that is detrimental to social relationships and have breathing problems that result in recurrent nocturnal awakenings, unrefreshing sleep, and excessive daytime sleepines —effects that together can substantially impair quality of life</p><p><a href="https://vmst.io/tags/obesity" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>obesity</span></a> <a href="https://vmst.io/tags/osa" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>osa</span></a> <a href="https://vmst.io/tags/stroke" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>stroke</span></a> <a href="https://vmst.io/tags/heart" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>heart</span></a> <a href="https://vmst.io/tags/nejm" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>nejm</span></a><br><a href="https://www.nejm.org/doi/full/10.1056/NEJMe2407117" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nejm.org/doi/full/10.1056/NEJM</span><span class="invisible">e2407117</span></a></p>
DrBob, Neurologist, 🧠Mechanic<p>““Blessed Be the Fruit”</p><p>The Contemporary Rise of Pronatalism</p><p>“In interviews, novelist Margaret Atwood explains that her inspiration for her 1985 novel The Handmaid’s Tale arose from the U.S. political climate of the time.</p><p>Specifically, changing voter demographics and policy attitudes after the civil rights and second-wave feminist movements prompted some Reagan-era politicians to build alliances with religious traditionalists.”</p><p><a href="https://vmst.io/tags/NEJM" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NEJM</span></a> <a href="https://vmst.io/tags/Pronatalism" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Pronatalism</span></a> <a href="https://vmst.io/tags/trump" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>trump</span></a> <a href="https://vmst.io/tags/jdvance" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>jdvance</span></a> <a href="https://vmst.io/tags/Christiannationalism" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Christiannationalism</span></a> <a href="https://vmst.io/tags/fascism" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>fascism</span></a><br><a href="https://www.nejm.org/doi/full/10.1056/NEJMp2410208" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nejm.org/doi/full/10.1056/NEJM</span><span class="invisible">p2410208</span></a></p>
IT News<p>Woman drips with sweat from a bite of food due to rare nerve-wiring mix-up - Enlarge (credit: Getty | MICHAEL KAPPELER) </p><p>The human body is f... - <a href="https://arstechnica.com/?p=2048913" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="">arstechnica.com/?p=2048913</span><span class="invisible"></span></a> <a href="https://schleuss.online/tags/gustatoryhyperhidrosis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>gustatoryhyperhidrosis</span></a> <a href="https://schleuss.online/tags/nerveregeneration" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>nerveregeneration</span></a> <a href="https://schleuss.online/tags/freyssyndrome" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>freyssyndrome</span></a> <a href="https://schleuss.online/tags/salivarygland" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>salivarygland</span></a> <a href="https://schleuss.online/tags/sweating" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>sweating</span></a> <a href="https://schleuss.online/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>science</span></a> <a href="https://schleuss.online/tags/health" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>health</span></a> <a href="https://schleuss.online/tags/nerves" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>nerves</span></a> <a href="https://schleuss.online/tags/nejm" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>nejm</span></a></p>
Winston Chiong<p>A few belated points about the surprising and slightly troubling <a href="https://neuromatch.social/tags/NEJM" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NEJM</span></a> study (<a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2400645" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nejm.org/doi/full/10.1056/NEJM</span><span class="invisible">oa2400645</span></a>) on cognitive motor dissociation in <a href="https://neuromatch.social/tags/DisordersOfConsciousness" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>DisordersOfConsciousness</span></a>, which I think have been underemphasized in the conversation so far:</p><p>The topline finding was that 25% of patients without observable responses to commands had fMRI or EEG evidence of awareness (physiologically meaningful activity modulation to specific commands). This is quite a bit higher than in earlier, smaller studies, many only using either fMRI or EEG. </p><p>A very surprising finding to me was in Figure S5. This shows even with the lowest possible bedside CRS-R score of 0, clinically doing nothing at the bedside, someone could have fMRI or EEG evidence of awareness. Some prior literature considers threshold scores in the range of 8 to 10, but the figure suggests that no bedside examination procedure can exclude preserved conscious awareness. This is super-humbling. </p><p>Also, 25% is really conservative, and almost certainly an underestimate. The fMRI and EEG tasks and statistical thresholds are demanding; maybe because they're from <a href="https://neuromatch.social/tags/cogsci" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>cogsci</span></a> research, they're designed to limit the likelihood of false positives. This comes at the cost of many false negatives, as seen in light blue (merely the known false negatives, there are still more undetected false negatives)--these patients follow commands at the bedside but their fMRI and EEG tests are negative. Also, given behavioral variability over time, serial assessments would have revealed more positives. While in science it's a priority to avoid false positives, arguably in the clinical setting false negative findings about consciousness are a bigger problem. </p><p>And: while this study used formal CRS-R scoring procedures from research, we know that informal clinical diagnoses of coma or the vegetative state are even less sensitive to signs of consciousness than the CRS-R. So overall in clinical settings we can presume there are many more patients falsely assessed as unconscious. </p><p>I don't do clinical work anymore with patients with disorders of consciousness, but I would take this study as a humbling reminder of how much we still don't know about consciousness and the brain. It reinforces the clinical teaching I received to treat every clinically comatose and vegetative person as if they might be covertly aware. Our bedside examination procedures and these new high-tech tests are highly specific for consciousness but also very insensitive and nonconcordant. </p><p>Philosophically and conceptually, there's important work to be done to design more sensitive and less stringent indicators of awareness, and to think more about the balance to strike between false positive and false negative findings in tests for these patients.</p><p><a href="https://neuromatch.social/tags/bioethics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bioethics</span></a> <a href="https://neuromatch.social/tags/neuroethics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>neuroethics</span></a></p>
IT News<p>Man suffers rare bee sting directly to the eyeball—it didn’t go well - Enlarge / Bees fly to their hive. (credit: Getty | Federico Gambarini) ... - <a href="https://arstechnica.com/?p=2034341" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="">arstechnica.com/?p=2034341</span><span class="invisible"></span></a> <a href="https://schleuss.online/tags/ophthalmology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ophthalmology</span></a> <a href="https://schleuss.online/tags/beesting" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>beesting</span></a> <a href="https://schleuss.online/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>science</span></a> <a href="https://schleuss.online/tags/health" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>health</span></a> <a href="https://schleuss.online/tags/nejm" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>nejm</span></a> <a href="https://schleuss.online/tags/eye" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>eye</span></a></p>
Wolfgang Hagen<p>Die <a href="https://wien.rocks/tags/Vogelgrippe" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Vogelgrippe</span></a> <a href="https://wien.rocks/tags/H5N1" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>H5N1</span></a> ging in einem einmaligen Event auf Rinder über. Das ist das Ergebnis einer im <a href="https://wien.rocks/tags/NEJM" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NEJM</span></a> veröffentlichten virologischen Untersuchung. Knapp zuvor war es zu einem Reassortment des Virus gekommen.</p><p>➡️ Eine zufällige Mutation sorgte also offenbar für eine bessere Anpassung an Rinder (und andere Säugetiere?).<br>➡️ Das Virus breitete sich dann wohl von Rind zu Rind aus.</p><p>Das kommt nicht überraschend, ist aber trotzdem keine gute Nachricht. Eine Anpassung des Virus an Säugetiere ist genau das, was wir nicht wollen.</p><p><a href="https://www.nejm.org/doi/full/10.1056/NEJMc2405495" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nejm.org/doi/full/10.1056/NEJM</span><span class="invisible">c2405495</span></a></p>
petersuber<p>Update. Kudos to the Association of Health Care Journalists (<a href="https://fediscience.org/tags/AHCJ" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>AHCJ</span></a>) for its campaign against the <a href="https://fediscience.org/tags/NEJM" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NEJM</span></a> embargo against news outlets serving physicians. <a href="https://fediscience.org/tags/NEJM" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NEJM</span></a> just dropped the embargo. <br><a href="https://healthjournalism.org/blog/2024/05/ahcj-advocacy-prompts-nejm-group-to-abandon-unfair-credential-policy/" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">healthjournalism.org/blog/2024</span><span class="invisible">/05/ahcj-advocacy-prompts-nejm-group-to-abandon-unfair-credential-policy/</span></a></p><p><a href="https://fediscience.org/tags/Embargoes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Embargoes</span></a> <a href="https://fediscience.org/tags/Journals" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Journals</span></a> <a href="https://fediscience.org/tags/Medicine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Medicine</span></a> <a href="https://fediscience.org/tags/ScholComm" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ScholComm</span></a></p>
petersuber<p>Update. Here's some background on the candid self-examination undertaken by the New England Journal of Medicine (<span class="h-card" translate="no"><a href="https://bird.makeup/users/nejm" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>nejm</span></a></span>, <a href="https://fediscience.org/tags/NEJM" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NEJM</span></a>).<br><a href="https://news.harvard.edu/gazette/story/2024/05/how-do-you-read-organizations-silence-over-rise-of-nazism/" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">news.harvard.edu/gazette/story</span><span class="invisible">/2024/05/how-do-you-read-organizations-silence-over-rise-of-nazism/</span></a> </p><p>"In December, one of the world’s leading medical journals…began a process of self-examination, publishing articles about…its handling of a series of key historical injustices in medicine, including eugenics, slavery, oppression of Native Americans, and, in an issue published in April, the rise of Nazi Germany."</p>
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