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#lipids

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Nina Davtian

Four weeks ago, my first co-authored @EuroGeosciences #preprint « #Reviews and syntheses: Best practices for the application of #marine #GDGTs as proxy for paleotemperatures: sampling, processing, analyses, interpretation, and archiving protocols » went online!
doi.org/10.5194/egusphere-2025
#Science #ScienceMastodon #AcademicMastodon
#Review #Consensus
#EGUsphere
#isoGDGTs #brGDGTs #TeamArchaea #TeamBacteria
#archaeal #bacterial #tetraether #lipids
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Nina Davtian

The last #scientific #publication from Devika Varma’s #PhD #thesis at @NIOZnieuws (nioz.nl/en/news/investigating-) is now published in #OrganicGeochemistry:
doi.org/10.1016/j.orggeochem.2
Many thanks to Isla Castañeda for the invitation to review this paper—yes, I signed the review report.
#Science #ScienceMastodon #AcademicMastodon
#GDGTs #isoGDGTs #TeamArchaea
#Archaeal #tetraether #lipids

www.nioz.nlInvestigating paleotemperature proxies based on archaeal hydroxylated tetraether lipidsUnderstanding past sea surface temperatures (SSTs) is crucial for reconstructing Earth's climate history. Devika Varma has focused her PhD research pr…
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Nina Davtian

On this #InternationalWomensDay, let me highlight two #WomenInSTEM.
First, Amy Cromartie, who leads the following @EuroGeosciences #preprint:
egusphere.copernicus.org/prepr
Second, Devika Varma, who recently defended her #PhD #thesis. Her PhD work at @NIOZnieuws aimed to investigate #paleotemperature indicators based on #archaeal hydroxylated #tetraether #lipids (OH-isoGDGTs):
nioz.nl/en/news/investigating-
#IWD #IWD25 #IWD2025
#Science #ScienceMastodon #AcademicMastodon
#GDGTs #brGDGTs #isoGDGTs
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egusphere.copernicus.orgUtilizing Probability Estimates from Machine Learning and Pollen to Understand the Depositional Influences on Branched GDGT in Wetlands, Peatlands, and LakesAbstract. Branched glycerol dialkyl glycerol tetraethers (brGDGTs) serve as critical molecular biomarkers for the quantitative reconstruction of past environments, ambient temperature and pH across various archives. Despite their success, numerous issues persist that limit their application. The distribution of brGDGTs varies significantly based on provenance, resulting in biases in environmental reconstructions that rely on fractional abundances and derived indices, such as the MBT’5ME. This issue is especially significant in shallow lakes, wetlands, and peatlands within semi-arid and arid regions, where ecosystems are sensitive to diverse environmental and climatic factors. Recent advancements, such as machine learning techniques, have been developed to identify changes in sources; however, these techniques are insufficient for detecting mixed source environments. The probability estimates derived from five machine learning algorithms are employed here to detect provenance changes in brGDGT downcore records and to identify periods of mixed provenance. A new global modern database (n=2301) was compiled to train, validate, test, and apply these algorithms to two sedimentary records. Our findings are corroborated by pollen and non-pollen palynomorphs obtained from the identical records. These microfossil proxies are utilized to discuss changes in provenance, hydrology, and ecology that influence the distribution of brGDGTs. Probability estimates derived from Random Forest with a sigmoid calibration are most effective in detecting changes in brGDGT distribution. Minor changes in the relative contributions of brGDGTs provenance can significantly influence the distribution of brGDGTs, especially regarding the MBT'5ME index. This study introduces a novel brGDGT wetland index aimed at monitoring potential biases arising from wetland development.
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Paul Houle

🧈 Dietary Lipids, Gut Microbiota, and Their Metabolites: Insights from Recent Studies

mdpi.com/2072-6643/17/4/639

MDPIDietary Lipids, Gut Microbiota, and Their Metabolites: Insights from Recent StudiesDietary lipid intake can influence the gut microbiota (GM) and their metabolites, such as short-chain fatty acids (SCFA) and bile acids, which are key mediators of health. The objective is to examine how dietary lipids’ quantity and quality influence the GM and metabolite profiles. A literature review of 33 studies in animals and humans was performed on the effects of saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), polyunsaturated fatty acids (PUFAs), trans-fatty acids (TFAs), and sterols on GM composition and gut-derived metabolites. The results show that diets rich in MUFAs, n-3 PUFAs, and short-chain FAs have the potential to enhance beneficial bacteria and metabolites. In addition, trans-palmitoleic acid, conjugated linoleic acid, and phytosterols may also have potentially beneficial effects on GM, but more research is needed. Medium-chain FAs and n-6 PUFAs have variable effects on the GM. Conversely, intakes of high-fat diets, long-chain SFAs, industrial TFAs, and cholesterol disrupt GM balance. In conclusion, animal studies clearly demonstrate that dietary fats influence the GM and related metabolites. Yet, human studies are limited. Therefore, well-designed human studies that consider the whole diet and baseline health status are needed to better understand the effects of dietary lipids on GM.
#food#nutrition#diet
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Victoria Stuart 🇨🇦 🏳️‍⚧️

Mitochondrial fatty acid oxidation drives senescence
science.org/doi/10.1126/sciadv

* cellular senescence: stress-induced irreversible cell cycle arrest in tumor suppression/aging
* pharmacological activation of fatty acid oxidation induced senescence in vitro/in vivo
* mitochondrial energy metabolism: critical role in senescence induction
* potential intervention to control senescence

#ageing#aging#senescence
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preLights

In June, @the_node, preLights & @focalplane_jcs hosted #SciCommConnect, a science communication event.

Here, we highlight one of the winners of the 3-minute research talk competition: Shreya Pramanik ⭐

Check out her wonderful talk and learn more about her research and career in the post below ⬇️ 👀

Interview: prelights.biologists.com/news/

preLightsIntroducing Shreya Pramanik - one of the SciCommConnect three-minute talk winners - preLightsIn June, the Node, preLights and FocalPlane hosted SciCommConnect, a science communication event focussed on learning new scicomm skills and networking with like-minded researchers. As part of the day, we hosted a three-minute research talk competition, and we were treated to 12 fantastic talks on a range of topics. We had two competition winners, Oliver[...] Read More
#interview#talk#scicomm
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Rhyothemis

C15:0 The Holy Grail of Healthy Aging

youtu.be/wpdExyBjkos?si=Bol_85

Very interesting video on pentadecanoic acid, aka fatty 15. I haven't yet read the scientific papers, so I haven't formed an opinion of how likely it is that this supplement will live up to what is being claimed.

If the claims are true, they could answer some longstanding questions/seeming contradictions regarding the effects of low-fat vs high-fat diary consumption, for instance the 'ice cream effect' and Parkinson's disease risk/progression.

I'm seriously considering trying it. Usually I'm a late adopter - but this one is really intriguing. I will read some papers first, though.

I have questions re: membrane stability (I thought we needed more fluid membranes) and also re: the effects of warming oceans on FA production.

YouTubeC15:0 The Holy Grail of Healthy AgingBy meetfatty15
#Aging#metabolomics#PentadecanoicAcid
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Science Updates

"Diet is so complex that it is often difficult to draw conclusive evidence from a single study," acknowledged Dr Clemens Wittenbecher. "Our approach of using lipidomics to combine intervention studies with highly controlled diets and prospective cohort studies with long-term health tracking can overcome current limitations in nutrition research."

#lipids #fats #diet #plants #biology #health #medicine #cardiology #research

labroots.com/trending/cell-and

LabrootsBlood Lipid Profiles Indicate Plant Oils are Healthier Than Animal Fats | Cell And Molecular BiologyNot all fats are equal. A new study has suggested that unsaturated fats from plant sources are far better for human health than saturated fats from animal | Cell And Molecular Biology
Continued thread
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Egon Willighagen

if you wonder why #epilipidnet WG4 was missing, that's the WG where we're involved. Florian Gruber (the chair) presented some recent work on lipids in our skins and how cholesterol modulates restructuring of the membranes and the tissue structure. I (co-chair) presented the @wikipathways work (tho I see I should not have left out the @bridgedb slide) and the state of the #lipids portal (lipids.wikipathways.org/).

lipids.wikipathways.orgRedirecting…
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