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#pathogenesis

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A systematic #review of #laboratory #investigations into the #pathogenesis of avian #influenza viruses in wild #avifauna of North #America

Source: Proceedings of the Royal Society Biological Sciences, AbstractThe lack of consolidated information regarding the response of wild bird species to infection with avian influenza virus (AIV) is a challenge to both conservation managers and researchers alike, with related sectors also impacted, such as public health and…

etidioh.wordpress.com/2024/10/

A systematic #[review of #laboratory #investigations into the #pathogenesis of avian #influenza viruses in wild #avifauna of North #America, BioRxIV: biorxiv.org/content/10.1101/20

This study represents the first comprehensive effort to compile available literature regarding the pathobiology of AIV's in all wild birds in over a decade. This database provides an opportunity to critically examine and assess what is known and identify where further insight is needed.

bioRxiv · A systematic review of laboratory investigations into the pathogenesis of avian influenza viruses in wild avifauna of North AmericaThe lack of consolidated information regarding wild bird species' response to avian influenza virus (AIV) infection is a challenge for conservation managers, researchers, and related sectors such as public health and commercial poultry. Such information could be used to model complex disease dynamics within communities, prioritize species for surveillance and conservation efforts, or identify species more likely to facilitate spillover into domestic animals or humans. Using two independent searches, we reviewed published literature for studies describing wild bird species experimentally infected with avian influenza to assess host species' relative susceptibility to AIVs. Additionally, we summarized broad-scale parameters for elements such as shedding duration and minimum infectious dose that can be used in transmission modeling efforts. Our synthesis documented that waterfowl (i.e., Anatidae) comprise the vast majority of published AIV pathobiology studies, whereas gulls and passerines were less represented in research despite evidence that they also are susceptible and contribute to high pathogenicity avian influenza disease dynamics. This study represents the first comprehensive effort to compile available literature regarding the pathobiology of AIV's in all wild birds in over a decade. This database provides an opportunity to critically examine and assess what is known and identify where further insight is needed. ### Competing Interest Statement The authors have declared no competing interest.

@Infoseepage Here another proof of what you're saying: #Pathogenesis of #H5N1 #Influenza Virus Infections in #Mice & #Ferret Models Differs According to #Respiratory Tract or #Digestive System Exposure, J Infect Dis.: academic.oup.com/jid/article/1

Our results demonstrated that exposure of digestive system to H5N1 influenza viruses could initiate infection either through the #tonsil, with spread to respiratory tissues, or through #intestinal infection, with spread to the liver and #pancreas.

OUP AcademicPathogenesis of H5N1 Influenza Virus Infections in Mice and Ferret Models Differs According to Respiratory Tract or Digestive System ExposureAbstract. Background Epidemiologic, clinical, and laboratory data suggest that H5N1 influenza viruses are transmitted through and predominantly affect the

An ex vivo #human precision-cut #lung slice #platform provides insight into #SARS-CoV-2 #pathogenesis and #antiviral drug #efficacy, J Virol.: journals.asm.org/doi/full/10.1

We identified early induction of specific #cytokines, especially IP-10 and IL-8, as potential predictors for severe #COVID19, & uncovered a hitherto unrecognized phenomenon that while infectious virus disappears at late times of infection, viral #RNA persists and lung histopathology commences.

A systematic #review of #laboratory #investigations into the #pathogenesis of avian #influenza viruses in wild #avifauna of North #America, BioRxIV, biorxiv.org/content/10.1101/20

This study represents the first comprehensive effort to compile available literature regarding the pathobiology of AIVs in all wild birds in over a decade.

bioRxiv · A systematic review of laboratory investigations into the pathogenesis of avian influenza viruses in wild avifauna of North AmericaThe lack of consolidated information regarding response of wild bird species to infection with avian influenza virus (AIV) is a challenge to both conservation managers and researchers alike, with related sectors also impacted, such as public health and commercial poultry. Using two independent searches, we reviewed published literature for studies describing wild bird species experimentally infected with avian influenza to assess host species' relative susceptibility to AIVs. Additionally, we summarize broad scale parameters for elements such as shedding duration and minimum infectious dose that can be used in transmission modeling efforts. Our synthesis shows that waterfowl (i.e., Anatidae) comprise the vast majority of published AIV pathobiology studies, whereas gulls and passerines were less represented in research despite evidence that they also are susceptible and contribute to highly pathogenic avian influenza disease dynamics. This study represents the first comprehensive effort to compile available literature regarding the pathobiology of AIVs in all wild birds in over a decade. This database can now serve as a tool to all researchers, providing generalized estimates of pathobiology parameters for a variety of wild avian families and an opportunity to critically examine and assess what is known and identify where further insight is needed. ### Competing Interest Statement The authors have declared no competing interest.

Divergent #Pathogenesis and #Transmission of Highly Pathogenic Avian #Influenza A(#H5N1) in #Swine, Emerg Infect Dis.: wwwnc.cdc.gov/eid/article/30/4

-- We assessed susceptibility of swine to avian and mammalian HPAI H5N1 clade 2.3.4.4b strains using a pathogenesis and transmission model. All strains replicated in the lung of pigs and caused lesions consistent with influenza A infection. However, viral replication in the nasal cavity and transmission was only observed with mammalian isolates.

Emerging Infectious Diseases journalDivergent Pathogenesis and Transmission of Highly Pathogenic Avian Influenza A(H5N1) in SwineHighly Pathogenic Avian Influenza A(H5N1) in Swine